Sulfatase 2 è un gene codificato dal simbolo SULF2. È noto anche come: Extracellular sulfatase Sulf-2; hSulf-2; SULF2; KIAA1247. Sulfatase 2 ha una massa di 100.46kDa e una lunghezza di amminoacidi di 870.
Offriamo 1 anticorpi contro Sulfatase 2, allevati nel Coniglio, che sono adatti per IHC con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Sommario di Entrez
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005
Specificità del tessuto
Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta.
Somiglianze di sequenza
Belongs to the sulfatase family.
Modifica post-translazionale
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Posizione cellulare
Endoplasmic reticulum. Golgi apparatus > Golgi stack. Cell surface.
Also localized on the cell surface.
