Synaptophysin è un gene codificato dal simbolo SYP. È noto anche come: Major synaptic vesicle protein p38; SYP. Synaptophysin ha una massa di 33.85kDa, una lunghezza di amminoacidi di 313, ed è implicato in Mental retardation, X-linked 96.
Offriamo 38 anticorpi contro Synaptophysin, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e ChIP con campioni derivati da Umano, Topo, Ratto, Bovino, Scimmia, Pollo e Criceto.
Informazioni su geni e proteine
Riepilogo UniProt
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Sommario di Entrez
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability.
Specificità del tessuto
Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3.
Coinvolgimento nella malattia
Mental retardation, X-linked 96: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Somiglianze di sequenza
Belongs to the synaptophysin/synaptobrevin family.
Modifica post-translazionale
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Posizione cellulare
Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cell junction > Synapse > Synaptosome.
