Transferrin Receptor è un gene codificato dal simbolo TFRC. È noto anche come: Transferrin receptor protein 1; TR; T9; p90; TFRC. Transferrin Receptor ha una massa di 84.87kDa, una lunghezza di amminoacidi di 760, ed è implicato in Immunodeficiency 46.
Offriamo 64 anticorpi contro Transferrin Receptor, allevati nel Coniglio, Topo, Capra e Ratto, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto e Furetto.
Informazioni su geni e proteine
Riepilogo UniProt
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
Sommario di Entrez
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified.
Coinvolgimento nella malattia
Immunodeficiency 46: An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia.
Somiglianze di sequenza
Belongs to the peptidase M28 family. M28B subfamily.
Modifica post-translazionale
N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Posizione cellulare
Cell membrane. Melanosome.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.