TRIB1 è un gene codificato dal simbolo TRIB1. È noto anche come: Tribbles homolog 1; TRB-1; G-protein-coupled receptor-induced gene 2 protein; GIG-2; SKIP1; C8FW; GIG2; TRB1. TRIB1 ha una massa di 41.01kDa e una lunghezza di amminoacidi di 372.
Offriamo 5 anticorpi contro TRIB1, allevati nel Coniglio e Capra, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
Specificità del tessuto
Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
