ULBP1 è un gene codificato dal simbolo ULBP1. È noto anche come: UL16-binding protein 1; ALCAN-beta; NKG2D ligand 1; N2DL-1; Retinoic acid early transcript 1I; N2DL1; RAET1I. ULBP1 ha una massa di 28kDa e una lunghezza di amminoacidi di 244.
Offriamo 3 anticorpi contro ULBP1, allevati nel Coniglio, che sono adatti per WB e IHC con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Sommario di Entrez
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Somiglianze di sequenza
Belongs to the MHC class I family.
Posizione cellulare
Cell membrane. Endoplasmic reticulum.
In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.
