VDAC3 è un gene codificato dal simbolo VDAC3. È noto anche come: Voltage-dependent anion-selective channel protein 3; VDAC-3; Outer mitochondrial membrane protein porin 3. VDAC3 ha una massa di 30.66kDa e una lunghezza di amminoacidi di 283.
Offriamo 2 anticorpi contro VDAC3, allevati nel Coniglio, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
Sommario di Entrez
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.
Specificità del tessuto
Widely expressed. Highest in testis.
Somiglianze di sequenza
Belongs to the eukaryotic mitochondrial porin family.
Modifica post-translazionale
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Posizione cellulare
Mitochondrion outer membrane.
