VMAT2 è un gene codificato dal simbolo SLC18A2. È noto anche come: Synaptic vesicular amine transporter; Monoamine transporter; Solute carrier family 18 member 2; Vesicular amine transporter 2; VAT2; SLC18A2; SVMT. VMAT2 ha una massa di 55.71kDa, una lunghezza di amminoacidi di 514, ed è implicato in Parkinsonism-dystonia, infantile, 2.
Offriamo 10 anticorpi contro VMAT2, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed:23363473). Requisite for vesicular amine storage prior to secretion via exocytosis.
Sommario di Entrez
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993
Coinvolgimento nella malattia
Parkinsonism-dystonia, infantile, 2: An autosomal recessive disorder characterized by infantile onset of abnormal movements, including parkinsonism, dystonia, and poor fine motor skills, as well as autonomic dysfunction, including abnormal sweating, cold extremities, and poor sleep. Some patients have variable degrees of developmental delay.
Somiglianze di sequenza
Belongs to the major facilitator superfamily. Vesicular transporter family.
Posizione cellulare
Cytoplasmic vesicle membrane.
