Gastrin è un gene codificato dal simbolo GAST. Comunemente indicato anche come: GAST; GAS. Gastrin ha una massa di 11.39kDa e una lunghezza di amminoacidi di 101.
Offriamo 3 proteine Gastrin
Informazioni su geni e proteine
Riepilogo UniProt
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Sommario di Entrez
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.
Somiglianze di sequenza
Belongs to the gastrin/cholecystokinin family.
Modifica post-translazionale
Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Posizione cellulare
Secreted.
