HDGF è un gene codificato dal simbolo HDGF. Comunemente indicato anche come: Hepatoma-derived growth factor; High mobility group protein 1-like 2; HMG-1L2; HMG1L2. HDGF ha una massa di 26.79kDa e una lunghezza di amminoacidi di 240.
Offriamo 1 proteine HDGF
Informazioni su geni e proteine
Riepilogo UniProt
Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618).
Sommario di Entrez
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Specificità del tessuto
Ubiquitous.
Somiglianze di sequenza
Belongs to the HDGF family.
Modifica post-translazionale
Sumoylated with SUMO1. Sumoylation prevents binding to chromatin.
Posizione cellulare
Nucleus. Cytoplasm. Secreted > Extracellular exosome.
Secreted by exosomes and is located inside the exosome (PubMed:27926477). May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477).
