KGF è un gene codificato dal simbolo FGF7. Comunemente indicato anche come: Fibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7; HBGF-7; Keratinocyte growth factor; FGF7. KGF ha una massa di 22.51kDa e una lunghezza di amminoacidi di 194.
Offriamo 3 proteine KGF
Informazioni su geni e proteine
Riepilogo UniProt
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
Sommario di Entrez
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
Specificità del tessuto
Epithelial cell.
Somiglianze di sequenza
Belongs to the heparin-binding growth factors family.
Posizione cellulare
Secreted.
