Persephin è un gene codificato dal simbolo PSPN. Comunemente indicato anche come: PSP; PSPN. Persephin ha una massa di 16.6kDa e una lunghezza di amminoacidi di 156.
Offriamo 2 proteine Persephin
Informazioni su geni e proteine
Riepilogo UniProt
Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
Sommario di Entrez
This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma.
Somiglianze di sequenza
Belongs to the TGF-beta family. GDNF subfamily.
Posizione cellulare
Secreted.
