TARC è un gene codificato dal simbolo CCL17. È noto anche come: C-C motif chemokine 17; CC chemokine Small-inducible cytokine A17; Thymus and activation-regulated chemokine; CCL17; SCYA17. TARC ha una massa di 10.51kDa e una lunghezza di amminoacidi di 94.
Offriamo 4 proteine TARC
Informazioni su geni e proteine
Riepilogo UniProt
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
Sommario di Entrez
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
Specificità del tessuto
Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.
Somiglianze di sequenza
Belongs to the intercrine beta (chemokine CC) family.
Posizione cellulare
Secreted.
