TNFSF18 è un gene codificato dal simbolo TNFSF18. È noto anche come: Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; GITRL; TL6. TNFSF18 ha una massa di 22.72kDa e una lunghezza di amminoacidi di 199.
Offriamo 3 proteine TNFSF18
Informazioni su geni e proteine
Riepilogo UniProt
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Sommario di Entrez
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
Specificità del tessuto
Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Somiglianze di sequenza
Belongs to the tumor necrosis factor family.
Posizione cellulare
Cell membrane.
