Ricombinante Anti-SOX11 Anticorpo [SOX11/3235R] (A250020)

Anti-SOX11 Antibody [SOX11/3235R]

Recombinant rabbit monoclonal [SOX11/3235R] antibody to SOX11.

This antibody recognizes a protein of ~47kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5%-10% of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

IHC-P

IHC-P: 2-4 µg/ml

Human

Recombinant fragment, around amino acids 300-400, of human SOX11 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

SOX11/3235R

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

47 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-SOX11 Antibody [SOX11/3235R] - BSA and Azide free (A253200).

MRD27, SOX11_HUMAN, SRY (sex determining region Y) box 11, SRY related HMG box gene 11, SRY-box 11, Transcription factor SOX-11