Ricombinante Anti-SOX2 Anticorpo [rSOX2/1791] (A250004)

Anti-SOX2 Antibody [rSOX2/1791]

Recombinant mouse monoclonal [rSOX2/1791] antibody to SOX2.

SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker.

IHC

IHC-P: 1-2 µg/ml

Human, Mouse

Recombinant fragment, within amino acids 176-305, of human SOX2 protein. The exact sequence is proprietary.

Mouse

Monoclonal

rSOX2/1791

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

34 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-SOX2 Antibody [rSOX2/1791] - BSA and Azide free (A253184).

ANOP3, cb236, Delta EF2a, lcc, MCOPS3, MGC148683, MGC2413, RGD1565646, Sex determining region Y box 2, SOX 2, SOX2_HUMAN, SRY (sex determining region Y) box 2, SRY box containing gene 2, SRY related HMG box 2, SRY related HMG box gene 2, SRY-box 2, Transcription factor SOX 2, Transcription factor SOX-2, ysb