Anti-TDP2 Anticorpo [TDP2/1258] (A252771)

Anticorpo monoclonale [TDP2/1258] di topo contro TDP2 per Flow Cytometry, IF e IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-TDP2 Antibody [TDP2/1258] - BSA and Azide free
Descrizione
Mouse monoclonal [TDP2/1258] antibody to TDP2.
Specificità
This antibody recognizes a protein of 41kDa, which is identified as TDP2. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
Applicazioni
Flow Cytometry, IF, IHC-P
Diluizioni consigliate
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant full-length human TDP2 protein.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
TDP2/1258
Isotipo
IgG2b
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
41 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Note generali
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-TDP2 Antibody [TDP2/1258] (A249591).
Sinonimi
5'-Tyr-DNA phosphodiesterase, 5'-tyrosyl-DNA phosphodiesterase, AD 022, AD022, dJ30M3.3, EAP 2, EAP II, EAP2, EAPII, ETS 1 associated protein 2, ETS 1 associated protein II, ETS1 associated protein 2, ETS1 associated protein II, ETS1-associated protein 2, ETS1-associated protein II, MGC111021, MGC9099, RP1-30M3.3, TRAF and TNF receptor associated protein, TRAF and TNF receptor-associated protein, TTRAP, TYDP2_HUMAN, Tyr DNA phosphodiesterase 2, Tyr-DNA phosphodiesterase 2, Tyrosyl DNA phosphodiesterase 2, Tyrosyl-DNA phosphodiesterase 2
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Prodotti alternativi a Anti-TDP2 Anticorpo [TDP2/1258] (A252771)

Inizio pagina