Ricombinante Anti-TMEM16A Anticorpo [rDG1/447] (A315736)

Anti-TMEM16A Antibody [rDG1/447]

Recombinant mouse monoclonal [rDG1/447] antibody to TMEM16A.

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.

IHC-P

Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.

IHC: 1-2 µg/ml

Human

Recombinant full-length human DOG-1 protein.

Mouse

Monoclonal

rDG1/447

IgG2b

Unconjugated

Protein A/G chromatography.

200 µg/ml

~114 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

ANO 1, ANO1, ANO1_HUMAN, Anoctamin 1, Anoctamin 1 calcium activated chloride channel, Anoctamin-1, Anoctamin1, Ca2+ activated Cl- channel, Calcium Activated Chloride Channel, Discovered on gastrointestinal stromal tumors protein 1, DOG 1, DOG1, FLJ10261, Membrane protein, Oral cancer overexpressed 2, Oral cancer overexpressed protein 2, ORAOV 2, ORAOV2, TAOS 2, TAOS2, TMEM 16A, Transmembrane protein 16A, Transmembrane protein 16A (eight membrane spanning domains), Tumor amplified and overexpressed sequence 2, Tumor-amplified and overexpressed sequence 2