Rabbit polyclonal antibody to Tyrosine Hydroxylase.
Specificità
This antibody recognises tyrosine hydroxylase (TH). Tyrosine hydroxylase catalyses the rate-limiting step in the biosynthetic pathway of the catecholamines dopamine (DA), norepinephrine, and epinephrine. The enzyme exists as a tetramer, with each subunit composed of an N-terminal regulatory domain and a C-terminal catalytic domain.Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.
Applicazioni
WB, IHC-P, IHC-Fr, IF
Diluizioni consigliate
IF: 1:1,000, IHC-Fr: 1:1,000, WB: 1:1,000
Reattività
Rat, Mammals, Grasshopper (Gastrimargus musicus), Rat, Mouse
Immunogeno
Tyrosine hydroxylase purified from pheochromocytoma.
Specie ospite
Rabbit
Clonalità
Polyclonal
Isotipo
IgG
Coniugare
Unconjugated
Concentrazione
Lot Specific
Peso molecolare
Approximately 60 kDa in rat caudate cell lysates.
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM HEPES, pH 7.5, with 0.01% BSA, 50% Glycerol, and 0.09% Sodium Azide.
Conservazione
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Note generali
Rabbit anti Rat tyrosine hydroxylase antibody recognizes tyrosine hydroxylase (TH). Tyrosine hydroxylase catalyses the rate-limiting step in the biosynthetic pathway of the catecholamines dopamine (DA), norepinephrine, and epinephrine. The enzyme exists as a tetramer, with each subunit composed of an N-terminal regulatory domain and a C-terminal catalytic domain. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease (Haavik et al. 1998).