Anti-UACA Anticorpo [AE-5] (A249692)

Anti-UACA Antibody [AE-5]

Mouse monoclonal [AE-5] antibody to UACA.

UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

Flow Cytometry, IF, WB

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml

Human, Mouse

Nuclei of myeloid leukemia biopsy cells.

Mouse

Monoclonal

AE-5

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

160 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-UACA Antibody [AE-5] - BSA and Azide free (A252872).

FLJ10128, KIAA1561, MGC141967, MGC141969, Nuclear membrane binding protein, NUCLING, UACA_HUMAN, Uveal autoantigen with coiled coil domains and ankyrin repeats, Uveal autoantigen with coiled-coil domains and ankyrin repeats