Anti-Von Willebrand Factor Anticorpo [3E2D10 + VWF635] (A250323)

Anti-Von Willebrand Factor Antibody [3E2D10 + VWF635]

Mouse monoclonal [3E2D10 + VWF635] antibody to Von Willebrand Factor.

von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi s sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.

IP, Flow Cytometry, IF, WB, IHC-P

IP: 1-2 µg / 500 µg protein lysate, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 845-949, of human vWF protein. The exact sequence is proprietary.

Mouse

Oligoclonal

3E2D10 + VWF635

IgG1, kappa [3E2D10] + IgG1, kappa [VWF635]

Protein A/G chromatography.

200 µg/ml

250 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Coagulation factor VIII , Coagulation factor VIII VWF, F8VWF, Factor VIII related antigen, von Willebrand antigen 2, von Willebrand antigen II, Von Willebrand disease, VWD, vWF, VWF_HUMAN