|Description:||Rabbit polyclonal antibody to Moesin.|
|Dilutions:||WB: 1:500 - 1:1000.|
|Immunogen:||A synthetic peptide of human MSN.|
|Formulation:||Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.|
|Storage:||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.|
|Function:||Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.|
|Tissue Specificity:||In all tissues and cultured cells studied.|
|Post-Translational Modification:||Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization.|
|Cellular Location:||Cell membrane. Cytoplasm > Cytoskeleton. Apical cell membrane. Cell projection > Microvillus membrane.
Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment.
|Synonyms:||Epididymis luminal protein 70 Antibody
Membrane organizing extension spike protein Antibody
Membrane-organizing extension spike protein Antibody
Moesin/anaplastic lymphoma kinase fusion protein Antibody
MSN/ALK fusion Antibody
|Information:||Target information shown above is from the UniProt Consortium.|