|Description:||Rabbit polyclonal antibody to P-Cadherin.|
|Applications:||WB, IHC, FC|
|Dilutions:||WB: 1:500 - 1:2000, IHC: 1:50 - 1:100, FC: 1:20 - 1:50.|
|Immunogen:||A synthetic peptide of human CDH3.|
|Formulation:||Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.|
|Storage:||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.|
|Function:||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Tissue Specificity:||Expressed in some normal epithelial tissues and in some carcinoma cell lines.|
|Involvement in Disease:||Hypotrichosis congenital with juvenile macular dystrophy: A disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life.
Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.
|Cellular Location:||Cell membrane.|