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Anti-PIK3R1 Antibody

Mouse monoclonal antibody to PIK3R1 from ABclonal (A10608).
Name: Anti-PIK3R1 Antibody
Description: Mouse monoclonal antibody to PIK3R1.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:1000, IHC: 1:50 - 1:200.
Reactivity: Human
Immunogen: Recombinant protein of human PIK3R1.
Protein Length: 724
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Tissue Specificity: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
Involvement in Disease: Agammaglobulinemia 7, autosomal recessive: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

SHORT syndrome: A rare, multisystem disease characterized by short stature, anomalies of the anterior chamber of the eye, characteristic facial features such as triangular facies, lack of facial fat, and hypoplastic nasal alae with overhanging columella, partial lipodystrophy, hernias, hyperextensibility, and delayed dentition. The clinical phenotype can include insulin resistance, nephrocalcinosis, and hearing deficits. Developmental milestones and cognition are normal.

Immunodeficiency 36: A primary immunodeficiency characterized by impaired B-cell function, hypogammaglobulinemia and recurrent infections.
Sequence Similarities: Belongs to the PI3K p85 subunit family.
Post-Translational Modification: Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
UniProt: P27986
Gene ID: 5295
Synonyms: GRB 1 Antibody
GRB1 Antibody
p85 Antibody
p85 alpha Antibody
P85A_HUMAN Antibody
Phosphatidylinositol 3 kinase associated p 85 alpha Antibody
Phosphatidylinositol 3 kinase regulatory 1 Antibody
Phosphatidylinositol 3 kinase regulatory subunit alpha Antibody
Phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 (p85 alpha) Antibody
Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha Antibody
Phosphatidylinositol 3-kinase regulatory subunit alpha Antibody
Phosphoinositide 3 kinase regulatory subunit 1 Antibody
Phosphoinositide 3 kinase regulatory subunit 1 (alpha) Antibody
Phosphoinositide 3 kinase regulatory subunit 1 (p85 alpha) Antibody
Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha) Antibody
PI3 kinase p85 subunit alpha Antibody
PI3-kinase regulatory subunit alpha Antibody
PI3-kinase subunit p85-alpha Antibody
PI3K Antibody
PI3K p85 Antibody
PI3K regulatory subunit alpha Antibody
PtdIns 3 kinase p85 alpha Antibody
PtdIns-3-kinase regulatory subunit alpha Antibody
PtdIns-3-kinase regulatory subunit p85-alpha Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of various cells, using PIK3R1 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to PIK3R1
Application: IHC
Host: Rabbit
Reactivity: Human
Immunogen: Fusion protein corresponding to a region derived from internal residues of human phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

£234

Description: Rabbit polyclonal antibody to Phospho-PIK3R1/PIK3R2/PIK3R3-Y467.
Application: WB
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£199 – £452

Description: Rabbit polyclonal antibody to PIK3R1
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human PIK3R1.

£234

Description: Rabbit polyclonal antibody to PIK3R1.
Application: WB, IHC
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Please Note: Anti-PIK3R1 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A10608
Size Price Quantity
100µl £307
200µl £452

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Lead Time: Currently 4-6 Days
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  • £35 to Europe