Necroptosis

Necroptosis is a form of programmed cell death that plays complex and diverse roles in cancer. Necroptosis is initiated by the activation of specific cell surface receptors called death receptors. These receptors belong to the tumour necrosis factor (TNF) receptor superfamily and include TNFR1, Fas, and TRAIL receptors. When these receptors are engaged by their respective ligands, a signalling cascade is triggered to induce necroptosis. Receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3) play crucial roles in necroptosis. Upon activation of death receptors, RIPK1 and RIPK3 form a complex known as the necrosome. The formation of this complex is essential for initiating necroptosis. Mixed lineage kinase domain-like protein (MLKL) is a downstream effector of necroptosis. Once the necrosome is formed, RIPK3 phosphorylates MLKL, leading to its activation. Phosphorylated MLKL then translocates to the plasma membrane, where it executes the downstream events of necroptosis. Activated MLKL forms oligomers that insert into the plasma membrane, leading to disruption of membrane integrity. This results in the leakage of intracellular contents and the release of damage-associated molecular patterns (DAMPs), which then trigger inflammation and immune responses. As a result of release of cell contents, necroptosis is associated with an inflammatory response, distinguishing it from apoptosis. The release of DAMPs and other pro-inflammatory molecules activates immune cells leading to the production of cytokines and recruitment of additional immune cells to the site of cell death. Necroptosis is tightly regulated to prevent excessive cell death and inflammation. Several proteins, such as cellular FLICE-inhibitory protein (cFLIP), caspase-8, and inhibitors of apoptosis proteins (IAPs), can negatively regulate necroptosis by inhibiting the formation or activity of the necrosome. In cancer, necroptosis can function as a tumour-suppressive mechanism by eliminating cancer cells and acts as a backup cell death pathway when apoptosis, the most common form of programmed cell death, is impaired. By promoting necroptosis, the body can eliminate cancer cells that would otherwise survive and contribute to tumour growth. Necroptosis can also induce immunogenic cell death by triggering an immune response against tumour cells. When cancer cells undergo necroptosis, they release danger signals and promote the activation of immune cells, such as dendritic cells and cytotoxic T cells. This immune response can enhance the antitumor immune response and contribute to tumour suppression. Necroptosis can also have pro-inflammatory effects, which can be both beneficial and detrimental in the context of cancer. In certain situations, necroptosis can trigger inflammation, leading to the recruitment of immune cells that can help fight tumours. However, chronic or excessive inflammation caused by necroptosis can also promote tumour progression by creating a microenvironment favourable for tumour growth, invasion, and angiogenesis. In some cases, cancer cells can exploit the necroptosis pathway to their advantage and develop resistance to cell death. They may acquire mutations or alterations in the components of the necroptosis signalling pathway, allowing them to evade necroptotic cell death and survive in unfavourable conditions. Targeting the necroptosis pathways has emerged as a potential therapeutic strategy. Promoting necroptosis in cancer cells or inhibiting necroptosis in certain contexts can have therapeutic implications, either by inducing cancer cell death or by preventing excessive inflammation and tissue damage associated with necroptosis. We offer a comprehensive product range of research tools for studying necroptosis, including TAK1 antibodies, FADD antibodies, RIP3 antibodies, FLIP antibodies, and Caspase-8 antibodies. Explore our full necroptosis product range below and discover more, for less.

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Western Blot - Anti-Caspase-8 Antibody (A12547) - Antibodies.com
(9)
Western Blot - Anti-TNF Receptor I Antibody (A305105) - Antibodies.com
(6)
Western Blot - Anti-MAP3K7 Antibody (B8132) - Antibodies.com
(7)
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Western Blot - Anti-MLKL Antibody (A9717) - Antibodies.com
Western Blot - Anti-TAK1 Antibody (A90981) - Antibodies.com
(6)
Western Blot - Anti-RIP3 Antibody (A17064) - Antibodies.com
(6)
Western Blot - Anti-RIP Antibody (A10146) - Antibodies.com
(4)
Western Blot - Anti-FADD Antibody [ARC51937] (A307153) - Antibodies.com
(5)
Western Blot - Anti-FADD Antibody (A307154) - Antibodies.com
(4)
Western Blot - Anti-cIAP2 Antibody (A8479) - Antibodies.com
(4)
Western Blot - Anti-MAP3K 7 Antibody (A83207)
(3)
Western Blot - Anti-MAP3K7 (phospho Ser439) Antibody (A8133) - Antibodies.com
(3)
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Western Blot - Anti-TNF Receptor I Antibody (A13494) - Antibodies.com
(3)
ELISA - Anti-Tak1 (phospho Thr184) Antibody (P12-1057) - Antibodies.com
(2)
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Western Blot - Anti-TAK1 (phospho Ser412) Antibody (A16432) - Antibodies.com
(2)
Immunohistochemistry - Anti-MAP3K7 Antibody (B8133) - Antibodies.com
(2)
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Immunohistochemistry - Anti-RIP3 Antibody (A304917) - Antibodies.com
(3)
Western Blot - Anti-MLKL Antibody (A90445) - Antibodies.com
(2)
Western Blot - Anti-Caspase-8 Antibody (A80797) - Antibodies.com
(3)
Immunohistochemistry - Anti-MLKL Antibody (A91618) - Antibodies.com
(3)
Western Blot - Anti-MLKL Antibody (A92971) - Antibodies.com
(3)
Western Blot - Anti-MAP3K7 (phospho Thr187) Antibody (A8132) - Antibodies.com
(2)
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Western Blot - Anti-MLKL Antibody [ARC2471] (A306584) - Antibodies.com
(3)
ELISA - Anti-TAK1 (phospho Thr184) Antibody (P12-1185) - Antibodies.com
(2)
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Western Blot - Anti-FADD Antibody (A14994) - Antibodies.com
(2)
Western Blot - Anti-FADD (phospho Ser194) Antibody (A0425) - Antibodies.com
(3)
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Western Blot - Anti-FADD (phospho Ser191) Antibody (A8503) - Antibodies.com
(3)
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Western Blot - Anti-cIAP1 Antibody [ARC0168] (A307415) - Antibodies.com
(3)
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Western Blot - Anti-TAK1 Antibody (A305052) - Antibodies.com
(2)
Western Blot - Anti-FADD Antibody (B0425) - Antibodies.com
(3)
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Western Blot - Anti-TAK1 (phospho Thr184) Antibody (A1123) - Antibodies.com
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Western Blot - Anti-FLIP Antibody (A14059) - Antibodies.com
(2)
Immunohistochemistry - Anti-TNF Receptor I Antibody (C0375) - Antibodies.com
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Western Blot - Anti-FADD Antibody (A307155) - Antibodies.com
(2)
Western Blot - Anti-Tak1 Antibody (R12-2373) - Antibodies.com
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Western Blot - Anti-cIAP1 Antibody (A308230) - Antibodies.com
(2)
Western Blot - Anti-Tak1 Antibody (R12-2374) - Antibodies.com
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Immunofluorescence - Anti-FADD Antibody (C13053) - Antibodies.com
(2)
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Western Blot - Anti-TAK1 (phospho Thr187) Antibody (A306209) - Antibodies.com
(2)
Western Blot - Anti-TAK1 Antibody [ARC0413] (A306692) - Antibodies.com
(2)
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Western Blot - Anti-MLKL Antibody (A307138) - Antibodies.com
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Western Blot - Anti-FADD Antibody (A89025) - Antibodies.com
Western Blot - Anti-MLKL Antibody (A90295) - Antibodies.com
(2)
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Western Blot - Anti-Caspase-8 Antibody (A80812) - Antibodies.com
Western Blot - Anti-MLKL (phospho Ser454) Antibody (A305626) - Antibodies.com
Western Blot - Anti-FADD Antibody (A92876) - Antibodies.com
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Immunohistochemistry - Anti-MLKL Antibody (A8882) - Antibodies.com
(2)

Showing 1-50 of 194 products

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