Growth Factors

Growth factors play multiple critical roles in cancer development and progression by stimulating cancer-relevant processes including the cell growth, proliferation, survival, and migration. They can be secreted by cancer cells themselves or by surrounding cells within the tumour microenvironment. There are numerous examples of their roles within normal physiology and development as they generally control signalling pathways involved in these processes. In cancer their roles are also various. For example, Epidermal Growth Factor (EGF) is a potent mitogen (inducer of cell proliferation) that binds to the epidermal growth factor receptor (EGFR) on cancer cells. EGF generally stimulates cancer cell proliferation, however, it also has important roles in angiogenesis and invasion. EGF also stimulates the proliferation of endothelial cells within the tumour microenvironment and promotes the migration of endothelial cells, enabling them to move towards the site where new blood vessels need to be formed, and influences the organization of endothelial cells into tubular structures, which are the basis for the formation of functional blood vessels. The growth factors acting more proximally on endothelial cells involved in tumour angiogenesis are the Vascular Endothelial Growth Factor (VEGF) family. The VEGF family consists of several members, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF), each of which has specific functions in angiogenesis. The VEGF family orchestrate a complex set of cellular events promoting blood vessel formation. These include endothelial cell activation, proliferation, migration, sprouting, pericyte recruitment, vessel maturation and modulation of vessel permeability. These processes collectively contribute to the formation of new functional blood vessels that are crucial for tumour growth. A third major family of growth factors involved in cancer growth are the PDGF (Platelet-Derived Growth Factors) growth factors which can be produced within the tumour microenvironment by various cell types, including cancer-associated fibroblasts (CAFs), tumour-associated macrophages (TAMs), and endothelial cells. Four PDGFs are known, PDGF-AA, PDGF-BB, PDGF-AB and PDGF-CC with each PDGF isoform binding to specific receptors on the cell surface, leading to various cellular responses. Transforming Growth Factor-beta (TGF-β) and Insulin-like Growth Factors (IGFs) are two additional growth factors implicated in cancer development. TGF-β is thought to have dual roles in cancer. In early stages, it acts as a tumour suppressor inhibiting cell proliferation. However, in advanced stages, it can promote tumour progression by enhancing angiogenesis, invasion, and metastasis. Insulin-like Growth Factors (IGFs) are like insulin and play an important role in cancer cell survival. They activate the IGF receptor on cancer cells, promoting their proliferation and, possibly more importantly, act as survival factors inhibiting apoptosis via activation of PI3K signalling. Three other types of growth factors have important roles in cancer development, Hepatocyte Growth Factor (HGF), Fibroblast Growth Factors (FGFs) and Colony-Stimulating Factors (CSFs). HGF (also known as scatter factor) binds to the c-Met receptor and stimulates cancer cell migration, invasion, and metastasis. It also has a role in angiogenesis and can induce epithelial-to-mesenchymal transition (EMT) in cancer cells, facilitating their invasive properties. FGFs are a family of growth factors involved in various cellular processes, including proliferation, differentiation, and angiogenesis. In cancer, FGFs are known to promote tumour growth, invasion, and angiogenesis. Finally, Colony-Stimulating Factors (CSFs) are growth factors that stimulate the production and maturation of various blood cell types, including white blood cells. In cancer, elevated levels of CSFs can contribute to tumour growth, invasion, and metastasis by recruiting immune cells to the tumour microenvironment. We provide a large product range of research reagents for investigating growth factors, including ErbB 2 antibodies, TNF alpha antibodies, Chromogranin A antibodies, TNF alpha ELISA Kits, and IGF1 ELISA Kits. Explore our full growth factors product range below and discover more, for less. Alternatively, you can explore our TNF, EGF, and FGF product ranges.

Showing 1- of 2,207 Products
Standard Curve - Hamster TNF alpha ELISA Kit (A74291) - Antibodies.com
Western Blot - Anti-TGF beta Antibody (MO-C40009A) - Antibodies.com
Immunohistochemistry - Anti-NLRP3 Antibody (A82453) - Antibodies.com
(2)
Western Blot - Anti-FGFR1 (phospho Tyr654) Antibody (A0481) - Antibodies.com
(3)
View Product10µg Trial Size
Western Blot - Anti-TNF Receptor I Antibody (A305105) - Antibodies.com
(6)
Immunohistochemistry - Anti-TNF alpha Antibody [P/T2] (A251072) - Antibodies.com
(3)
Immunohistochemistry - Anti-TNFA Antibody (C10265) - Antibodies.com
(7)
View Product10µg Trial Size
Immunohistochemistry - Anti-Her 2 Antibody (V0083) - Antibodies.com
(12)
View Product10µl Trial Size
Western Blot - Anti-Smad2 Antibody (A93131) - Antibodies.com
(9)
Western Blot - Anti-CYP17A1 Antibody (A84204) - Antibodies.com
(2)
Antibodies.com Image Placeholder - Discover more for less
View Product10µg Trial Size
Immunohistochemistry - Anti-TNF alpha Antibody [SPM543] (A251071) - Antibodies.com
(2)
Western Blot - Anti-CHGA Antibody (A84217)
(5)
Western Blot - Anti-VEGFR2 Antibody (B7254) - Antibodies.com
(8)
View Product10µg Trial Size
Antibodies.com Image Placeholder - Discover more for less
Western Blot - Anti-TGF beta 1 Antibody (A92358) - Antibodies.com
(7)
Western Blot - Anti-VEGFA Antibody (A14925) - Antibodies.com
(4)
Western Blot - Anti-IGF1 Antibody (A88771) - Antibodies.com
(3)
Western Blot - Anti-PDGF Receptor beta Antibody (B7194) - Antibodies.com
(4)
View Product10µg Trial Size
Immunohistochemistry - Anti-TNF alpha Antibody [P/T2] - BSA and Azide free (A254349) - Antibodies.com
(3)
Western Blot - Anti-FGF2 Antibody (A11129) - Antibodies.com
(7)
Immunohistochemistry - Anti-TNF alpha Antibody [4C6-H8] (A251070) - Antibodies.com
(2)
Western Blot - Anti-FGFR1 Antibody (B0480) - Antibodies.com
(3)
View Product10µg Trial Size
Western Blot - Anti-Chromogranin A Antibody [ARC1643] (A307702) - Antibodies.com
(6)
Western Blot - Anti-IGF1 Antibody (A83119)
(4)
Western Blot - Anti-Amphiregulin Antibody (A89920) - Antibodies.com
(6)
Western Blot - Anti-Smad2 Antibody [ARC0343] (A307856) - Antibodies.com
(5)
Western Blot - Anti-TNAP3 Antibody (C10444) - Antibodies.com
(4)
View Product10µg Trial Size
Western Blot - Anti-NLRP3 Antibody (A5652) - Antibodies.com
(2)
Antibodies.com Image Placeholder - Discover more for less
Immunohistochemistry - Anti-HER2 Antibody [ERBB2/4376R] - BSA and Azide free (A278563) - Antibodies.com
(4)
View ProductMonospecific AntibodyRecombinant Antibody
Western Blot - Anti-FGFR1 Antibody [ARC53424] (A306276) - Antibodies.com
(6)
Western Blot - Anti-TGF beta Receptor I Antibody (B1126) - Antibodies.com
(4)
View Product10µg Trial Size
Immunohistochemistry - Anti-TNF alpha Antibody (A12596) - Antibodies.com
(4)
Immunohistochemistry - Anti-TNF alpha Antibody [4C6-H8] - BSA and Azide free (A254347) - Antibodies.com
(2)
Immunohistochemistry - Anti-TNF alpha Antibody [SPM543] - BSA and Azide free (A254348) - Antibodies.com
(2)
Western Blot - Anti-FGF2 Antibody [ARC0618] (A308407) - Antibodies.com
(6)
View ProductKO Validated
Immunohistochemistry - Anti-TNF alpha Antibody [TNFA/1172] (A251069) - Antibodies.com
(6)
Western Blot - Anti-Smad1 Antibody (A309166) - Antibodies.com
(6)
View ProductKO Validated
Immunohistochemistry - Anti-TRAF2 Antibody (A84190)
(5)
Immunohistochemistry - Anti-TNF alpha Antibody [TNF706] - BSA and Azide free (A254350) - Antibodies.com
(3)
Western Blot - Anti-TRAF2 Antibody [ARC51292] (A305567) - Antibodies.com
(6)
Immunohistochemistry - Anti-TNF alpha Antibody [TNF706] (A251073) - Antibodies.com
(3)
Western Blot - Anti-HSD17B1 Antibody (A16800) - Antibodies.com
(5)
Western Blot - Anti-CD70 Antibody (A11503) - Antibodies.com
(5)
Western Blot - Anti-Smad1 Antibody (A13190) - Antibodies.com
(2)
Immunofluorescence - Anti-TGF beta 1 Antibody (A89925) - Antibodies.com
Western Blot - Anti-TNF12 Antibody (C10105) - Antibodies.com
(5)
View Product10µg Trial Size
Immunofluorescence - Anti-HER2 Antibody [HRB2/451] (A248448) - Antibodies.com
(6)
View ProductMonospecific Antibody
Immunohistochemistry - Anti-Chromogranin A Antibody [CHGA/798] - BSA and Azide free (A251387) - Antibodies.com
(7)

Showing 1-50 of 2,207 products

Search Filters Main Menu Contact Us 0Checkout
Top