NFkB Pathway

NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) is an important transcription factor involved in a variety of cellular processes relevant to cancer, including inflammation, immune responses, and cell survival. It plays a significant role in cancer development and progression by regulating the expression of many genes that are involved in cell proliferation, apoptosis resistance, angiogenesis, invasion, and metastasis. The NF-kB signalling pathway consists of a family of transcription factors, primarily composed of five subunits: p50, p52, p65 (RelA), RelB, and c-Rel. These subunits can form homodimers or heterodimers and are normally sequestered in the cytoplasm by inhibitors called IkBs (inhibitor of kappa B proteins). In response to various stimuli including cytokines, pathogens, or genotoxic stress, the NF-kB pathway is activated, leading to the degradation of IkBs through phosphorylation and ubiquitination, allowing the NF-kB subunits to translocate into the nucleus. Once in the nucleus, NF-kB binds to specific DNA sequences, known as κB sites (or NFκB response elements), and promotes the transcription of target genes involved in inflammation, cell survival, and other cancer-related processes. In cancer, aberrant activation of the NF-kB pathway is common. It can be triggered by various factors, including chronic inflammation, DNA damage, oncogenes, and tumour suppressor gene mutations. The persistent activation of NF-kB contributes to tumour growth and progression through several mechanisms: 1) NF-kB promotes cell survival and inhibits apoptosis by upregulating anti-apoptotic genes such as Bcl-2 and inhibitors of apoptosis proteins (IAPs). This prevents cancer cells from undergoing apoptosis; 2) NF-kB stimulates the expression of genes involved in inflammation and immune responses, creating a pro-inflammatory microenvironment that supports tumour growth and progression. Inflammation can induce the production of growth factors, cytokines, and chemokines that further promote angiogenesis, tissue remodelling, and cancer cell invasion; 3) NF-kB enhances the expression of genes involved in cell cycle progression and proliferation, contributing to uncontrolled cell growth in cancer cells. It can upregulate cyclins, cyclin-dependent kinases (CDKs), and growth-promoting factors, facilitating cell cycle progression and tumour cell proliferation; 4) NF-kB has also been implicated in promoting tumour angiogenesis. It induces the expression of pro-angiogenic factors such as VEGF and promotes endothelial cell survival and migration; 5) NF-kB also plays a role in cancer metastasis by regulating the expression of genes involved in epithelial-to-mesenchymal transition (EMT), a process where cancer cells acquire invasive and migratory properties. Overall, the dysregulation of NF-kB signaling contributes significantly to cancer development and progression by promoting cell survival, inflammation, proliferation, angiogenesis, and metastasis. We offer a large product range of research reagents for studying the NFkB pathway, including NF-kB p65 antibodies, Bcl10 antibodies, c-Rel antibodies, IKB alpha antibodies, and NF-kB p65 ELISA Kits. Explore our full NFkB pathway product range below and discover more, for less.

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Western Blot - Anti-NF-kappaB p65 (phospho Ser536) Antibody (A7171) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 (phospho Ser276) Antibody (A7169) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 (acetyl Lys310) Antibody (D0018) - Antibodies.com
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Western Blot - Anti-I kappa B alpha (phospho Ser32 + Ser36) Antibody (A7124) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 Antibody (D0038) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 (phospho Ser468) Antibody (A7170) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 Antibody (B7169) - Antibodies.com
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Western Blot - Anti-IkappaB-alpha Antibody (C10481) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 Antibody (B8049) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 (phospho Thr254) Antibody (A7172) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 (phospho Ser529) Antibody (A7162) - Antibodies.com
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Flow Cytometry - Anti-NF-kB p65 Antibody [PCRP-RELA-2B6] - BSA and Azide free (A253058) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 Antibody (B7170) - Antibodies.com
(4)
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Western Blot - Anti-NF-kappaB p65 Antibody (B7173) - Antibodies.com
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Western Blot - Anti-BCL10 Antibody (C13030) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 Antibody (B7171) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 (phospho Ser311) Antibody (A7163) - Antibodies.com
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Western Blot - Anti-IkappaB-alpha Antibody (B7116) - Antibodies.com
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Immunohistochemistry - Anti-NF-kappaB p65 (phospho Thr435) Antibody (A7173) - Antibodies.com
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Flow Cytometry - Anti-NF-kB p65 Antibody [PCRP-RELA-1E3] (A249877) - Antibodies.com
(6)
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Flow Cytometry - Anti-NF-kB p65 Antibody [PCRP-RELA-2B6] (A249878) - Antibodies.com
(4)
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Western Blot - Anti-NF-kappaB p65 Antibody (B7162) - Antibodies.com
(4)
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Western Blot - Anti-NF-kappaB p65 Antibody (B7172) - Antibodies.com
(3)
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Flow Cytometry - Anti-NF-kB p65 Antibody [PCRP-RELA-1E3] - BSA and Azide free (A253057) - Antibodies.com
(6)
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Immunohistochemistry - Anti-BCL10 Antibody [BL10/411] - BSA and Azide free (A253634) - Antibodies.com
(4)
Immunohistochemistry - Anti-IkappaB-alpha Antibody (B7124) - Antibodies.com
(2)
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Immunohistochemistry - Anti-BCL10 Antibody [BL10/2988R] - BSA and Azide free (A253638) - Antibodies.com
(4)
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Immunohistochemistry - Anti-IkappaB-alpha (phospho Tyr305) Antibody (A1053) - Antibodies.com
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Immunohistochemistry - Anti-BCL10 Antibody [BL10/411] (A250454) - Antibodies.com
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Immunohistochemistry - Anti-CARD11 Antibody (A83910) - Antibodies.com
(2)
Western Blot - Anti-NF-kappaB p65 Antibody (B0525) - Antibodies.com
(3)
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Immunohistochemistry - Anti-BCL10 Antibody [BL10/2988R] (A250458) - Antibodies.com
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Western Blot - Anti-NFκB-p65 (acetyl Lys218) Antibody (D12160) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 Antibody (B7163) - Antibodies.com
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Western Blot - Anti-NF-kappaB p65 Antibody (R12-3091) - Antibodies.com
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Western Blot - Anti-Rel Antibody (B7211) - Antibodies.com
(3)
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Immunohistochemistry - Anti-BCL10 Antibody [SPM520] - BSA and Azide free (A253634) - Antibodies.com
(2)
Immunohistochemistry - Anti-IkappaB-alpha Antibody (B1053) - Antibodies.com
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Immunohistochemistry - Anti-RelB (phospho Ser552) Antibody (A7212) - Antibodies.com
(2)
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Western Blot - Anti-Rel (phospho Ser503) Antibody (A7211) - Antibodies.com
(3)
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Immunohistochemistry - Anti-BCL10 Antibody [SPM520] (A250454) - Antibodies.com
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Western Blot - Anti-REL Antibody (A84787) - Antibodies.com
(2)
Western Blot - Anti-CARD11 Antibody (C12113) - Antibodies.com
(2)
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Immunohistochemistry - Anti-IkappaB-alpha (phospho Tyr42) Antibody (A7116) - Antibodies.com
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Immunohistochemistry - Anti-NF-kB p65 Antibody [RM273] (A121413) - Antibodies.com
(2)
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Immunohistochemistry - Anti-NF-kappaB p65 (phospho Thr505) Antibody (A0525) - Antibodies.com
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Western Blot - Anti-IkappaB-alpha Antibody (R12-2938) - Antibodies.com
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Showing 1-50 of 164 products

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