Various types of receptors play important roles in regulating apoptosis, particularly in the extrinsic mode of programmed cell death. Death receptors are involved, such as Fas (CD95), TNF receptor 1 (TNFR1), and TRAIL receptors (DR4 and DR5), belonging to the tumour necrosis factor (TNF) receptor superfamily. These are cell surface receptors that initiate apoptosis upon binding to their respective ligands, including Fas ligand (FasL), TNF-alpha, and TNF-related apoptosis-inducing ligand (TRAIL). Activation of death receptors then triggers the formation of the Death-Inducing Signalling Complex (DISC), leading to caspase activation and apoptosis. In immunology, receptors also play critical roles in control of T and B cell numbers. The T Cell Receptor (TCR) plays a crucial role in T cell survival and recognizes specific antigens presented by antigen-presenting cells (APCs) through major histocompatibility complex (MHC) molecules. Fas (CD95) and FasL are also involved in T cell apoptosis regulation. Engagement of Fas by FasL triggers the extrinsic apoptotic pathway in T cells, leading to caspase activation and apoptosis. TRAIL-R can similarly induce apoptosis upon binding to its ligand, TRAIL in T cells. TRAIL-R signalling contributes to the regulation of T cell numbers, particularly in situations where T cells are exposed to cytotoxic stimuli or encounter infected or transformed cells. Other important T cell receptors include CD28 and CTLA-4, co-stimulatory receptors expressed on T cells. CD28 provides co-stimulation upon binding to its ligands, CD80 and CD86 expressed on APCs, promoting T cell activation and survival. In contrast, CTLA-4 competes with CD28 for binding to CD80 and CD86 and delivers an inhibitory signal that can lead to T cell apoptosis. Finally, Programmed Cell Death Protein 1 (PD-1) is an inhibitory receptor expressed on activated T cells. It interacts with its ligands, PD-L1 and PD-L2, which are expressed on various cell types. Engagement of PD-1 by its ligands both dampens T cell responses and can induce apoptosis. The control of B cell numbers is similarly regulated by apoptosis and involves several specific receptors and signalling pathways. The B Cell Receptor (BCR) is a membrane-bound immunoglobulin molecule expressed on the surface of B cells. It recognizes specific antigens and initiates signalling cascades that regulate B cell survival or apoptosis. B cells that encounter self-antigens with high affinity through the BCR can undergo apoptosis during negative selection in the bone marrow. Fas (also known as CD95) is expressed on various cell types, including B cells. Fas-FasL interactions can also regulate B cell apoptosis, particularly during the germinal centre reaction and immune response contraction. The BAFF Receptor (BAFF-R) on B cells binds to BAFF, a cytokine belonging to the tumour necrosis factor (TNF) family and also plays a critical role in B cell survival. Upon ligand binding BAFF-R promotes B cell survival by activating prosurvival signalling pathways, with insufficient BAFF signalling leading to apoptosis. Finally, Signalling Lymphocytic Activation Molecule (SLAM) family receptors, including SLAM, CD84, and CD150, are expressed on B cells and other immune cells. These receptors also regulate B cell survival and apoptosis by interacting with adapter proteins and activating downstream signalling pathways. We provide a comprehensive product range of research reagents for studying apoptotic receptors, including PD1 antibodies, Fas antibodies, CD137 antibodies, IGFBP3 ELISA Kits, and Galectin 1 ELISA Kits. Explore our full apoptotic receptors product range below and discover more, for less. Alternatively, you can explore our Death Receptors, Associated Proteins, and Decoy Receptors product ranges.