Methyl Lysine

Methyl lysine is an epigenetic modification that influences chromatin structure and gene expression. Lysine methylation occurs primarily on histone proteins and is regulated by histone methyltransferases (HMTs) and histone demethylases. Lysine residues within histone tails modified by methylation can result in either mono-, di-, or trimethylation states and serve as signals that modulate chromatin accessibility and the recruitment of chromatin binding proteins. EZH2 is an HMT that is part of the Polycomb Repressive Complex 2 (PRC2) and contains a Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain. EZH2 primarily catalyses the trimethylation of histone H3 lysine 27 (H3K27me3), associated with gene silencing. Additional SET domain-containing HMTs include SETD1A and SETD1B, members of the SET1/COMPASS complex which catalyse the mono-, di-, and trimethylation of histone H3 lysine 4 (H3K4me1/2/3), associated with transcriptional activation. SET7/9 (SET Domain Bifurcated 1) also contains a SET domain and catalyses the mono-methylation of histone H3 lysine 4 (H3K4me1). SET7/9 is involved in transcriptional regulation and has roles in cell cycle control and DNA repair. SETDB1 (SET Domain Bifurcated 1), is a SET domain containing HMT catalysing trimethylation of histone H3 lysine 9 (H3K9me3) and associated with transcriptional repression. SETDB1 is involved in gene silencing and heterochromatin formation. Conversely, histone lysine demethylases remove methyl groups from lysine residues on histone proteins. They include: 1) LSD1/KDM1A (Lysine-Specific Demethylase 1A), a flavin-dependent amine oxidase-type demethylase that primarily demethylates mono- and di-methylated lysine 4 (H3K4me1/2) on histone H3. It can either promote transcriptional activation by demethylating H3K4me2 at gene promoters or contribute to gene repression by removing H3K4me1/2 from enhancers or other regulatory elements; 2) Members of the KDM2/JHDM1 family, including KDM2A and KDM2B, are Jumonji C (JmjC) domain-containing demethylases, primarily associated with the demethylation of H3K36me2/3 and can target H3K4me3 in specific contexts. KDM2 demethylases are involved in transcriptional repression, heterochromatin formation, and DNA damage response; 3) KDM3/JHDM2 family, including KDM3A, KDM3B, and KDM3C, are also JmjC domain-containing demethylases that primarily target H3K9me1/2, contributing to transcriptional activation; 4) KDM4/JMJD2 family that includes KDM4A, KDM4B, KDM4C, and KDM4D contain JmjC domains and target trimethylated lysine residues, with a preference for H3K9me3 and H3K36me3. KDM4 demethylases play roles in transcriptional activation and repression, DNA repair, and cellular processes related to chromatin dynamics; 5) KDM5/JARID1 family, which include KDM5A, KDM5B, KDM5C, and KDM5D, contain JmjC domains and primarily demethylate trimethylated lysine 4 (H3K4me3), contributing to transcriptional repression. They are often associated with Polycomb repressive complexes and heterochromatin formation. Finally, chromodomain proteins, like HP1 (Heterochromatin Protein 1), specifically interact with methyl lysine marks on histones. HP1 recognizes histone H3 lysine 9 trimethylation (H3K9me3), a mark often associated with heterochromatin and gene repression. HP1's binding to H3K9me3 facilitates the formation and maintenance of repressive chromatin structures. PHD (Plant Homeo Domain) finger-containing proteins, such as ING2, also recognize methyl lysine marks, specifically H3K4me3, associated with active gene promoters. ING2 interacts with H3K4me3 and contributes to chromatin remodelling and transcriptional activation. We provide a comprehensive product catalogue of research tools for investigating methyl lysine, including HP1 alpha antibodies, WDR5 antibodies, and UHRF1 antibodies. Explore our full methyl lysine product range below and discover more, for less.

Showing 1- of 64 Products
Western Blot - Anti-CBX5 Antibody (A82447) - Antibodies.com
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Western Blot - Anti-HP1 alpha Antibody [ARC0244] (A308742) - Antibodies.com
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Western Blot - Anti-UHRF1 Antibody (A9042) - Antibodies.com
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Western Blot - Anti-CBX3 Antibody (A83707) - Antibodies.com
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Western Blot - Anti-HP1 alpha Antibody (A88817) - Antibodies.com
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Western Blot - Anti-HP1 gamma Antibody (B8236) - Antibodies.com
(3)
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Western Blot - Anti-WDR5 Antibody (A89559) - Antibodies.com
Western Blot - Anti-PHF19 Antibody (A10284) - Antibodies.com
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Western Blot - Anti-CBX5 Antibody (C10620) - Antibodies.com
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Western Blot - Anti-HP1 alpha Antibody (A88778) - Antibodies.com
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Immunohistochemistry - Anti-HP1 alpha Antibody (B8262) - Antibodies.com
(2)
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Western Blot - Anti-GLYR1 Antibody (A10604) - Antibodies.com
Western Blot - Anti-CBX3 Antibody (A83706) - Antibodies.com
Immunohistochemistry - Anti-CHD7 Antibody (A84388) - Antibodies.com
Immunofluorescence - Anti-EMSY Antibody (A91953) - Antibodies.com
Western Blot - Anti-HP1 gamma (phospho Ser93) Antibody (A8236) - Antibodies.com
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Western Blot - Anti-EMSY Antibody (A9800) - Antibodies.com
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Western Blot - Anti-HP1alpha Antibody (R12-2892) - Antibodies.com
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Immunofluorescence - Anti-L3MBTL1 Antibody (A10056) - Antibodies.com
(2)
Western Blot - Anti-UHRF1 Antibody (A83277) - Antibodies.com
Western Blot - Anti-CBX5 Antibody (A83586) - Antibodies.com
Western Blot - Anti-WDR5 Antibody [ARC0769] (A305612) - Antibodies.com
Immunohistochemistry - Anti-HP1 alpha (phospho Ser92) Antibody (A8262) - Antibodies.com
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Western Blot - Anti-FAM208A Antibody (A88578) - Antibodies.com
Standard Curve - Human TZP ELISA Kit (A246890) - Antibodies.com
Standard Curve - Human UHRF1 ELISA Kit (A246977) - Antibodies.com
Standard Curve - Human WDR5 ELISA Kit (A303017) - Antibodies.com
Standard Curve - Human GLYR1 ELISA Kit (A303287) - Antibodies.com
Western Blot - Anti-UHRF1 Antibody (A91418) - Antibodies.com
Western Blot - Anti-Chd7 Antibody (A93196) - Antibodies.com
Anti-CBX5 Antibody from Bioworld Technology (BS9876M) - Antibodies.com
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Western blot - CBX5 Antibody from Signalway Antibody (32158) - Antibodies.com
(4)
Anti-CBX5 Antibody from Bioworld Technology (BS6151) - Antibodies.com
(3)
CBX5 Monoclonal Antibody from Signalway Antibody (27012) - Antibodies.com
(2)
Anti-CBX5 (K69) Antibody from Bioworld Technology (BS1999) - Antibodies.com
(2)
Western Blot - HP1 gamma (phospho Ser93) Cell Based ELISA Kit (CBP1792) - Antibodies.com
(4)
Western Blot - HP1 gamma Cell Based ELISA Kit (CB5341) - Antibodies.com
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Anti-UHRF1 (ChIP Grade) Antibody from Bioworld Technology (BS7227) - Antibodies.com
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Western blot - UHRF1 Antibody from Signalway Antibody (32666) - Antibodies.com
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Anti-WDR5 Antibody from FabGennix (WDR5-101AP) - Antibodies.com
WDR5 Antibody from Signalway Antibody (42847) - Antibodies.com
(3)
Western Blot - CBX5 Cell Based ELISA Kit (CB5894) - Antibodies.com
(4)
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Western blot - WDR5 Antibody from Signalway Antibody (32556) - Antibodies.com
(2)
Anti-WDR5 Antibody from Bioworld Technology (BS7354) - Antibodies.com
Anti-C11orf30 Antibody from Bioworld Technology (BS7931) - Antibodies.com
(2)
Anti-UHRF1 (N-terminus) Antibody from Bioworld Technology (MB0055) - Antibodies.com
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Anti-CBX5 Antibody from Bioworld Technology (MB0063) - Antibodies.com
(2)
L3MBTL antibody from Signalway Antibody (22754) - Antibodies.com
(2)

Showing 1-50 of 64 products

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