Receptors

Antibody receptors, also known as immunoglobulin receptors, are crucial components of the immune system that mediate the recognition and binding of antibodies (immunoglobulins) to specific antigens. The major forms of antibody receptors are the B cell receptor (BCR) and the Fc receptor (FcR). These receptors are critical components of the immune system and play essential roles in antigen recognition, immune response initiation, and immune cell interactions. These receptors are found on various immune cells and tissues and play essential roles in immune responses, including antigen presentation, antibody-mediated cellular functions, and the regulation of immune activation. B cells express membrane-bound antibody molecules as their BCRs. BCRs consist of antibody heavy and light chains and have dual functions in both antigen binding and in cell signalling. When the BCR recognizes an antigen, it initiates intracellular signalling, leading to B cell activation, proliferation, and differentiation into antibody-producing plasma cells. An additional type of antibody receptors are the Follicular Dendritic Cell (FDC) receptors found in germinal centres of lymphoid tissues which display immune complexes (antibodies bound to antigens) on their surfaces. These complexes can serve as antigen reservoirs and facilitate the selection of high-affinity B cells during affinity maturation. Fc receptors are expressed on the surfaces of various immune cells, including macrophages, neutrophils, natural killer cells, and certain dendritic cell subsets. These receptors specifically bind to the constant (Fc) region of antibodies. The engagement of FcRs with antibody-bound targets triggers various effector functions, such as phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and the release of inflammatory mediators. Finally, Neonatal Fc Receptors (FcRn) play an important role in regulating the transport and half-life of IgG antibodies in the circulation. It is responsible for rescuing IgG from degradation within endosomal compartments by recycling IgG back into the bloodstream. Antibody receptors have various functions in the body. BCRs, expressed on the surface of B cells, for example are critical for recognizing and binding antigens. When an antigen matches the variable regions of the BCR, it triggers B cell activation, leading to the production of specific antibodies against the antigen. Fc receptors on antigen-presenting cells (APCs) are also critical as they facilitate the uptake and presentation of antigens to T cells. This interaction is crucial for the initiation of adaptive immune responses. Fc receptors on immune cells interact with the Fc region of antibodies, leading to various effector functions. For example, Fc receptors on macrophages enable the phagocytosis of antibody-coated pathogens, whilst Fc receptors on NK cells mediate ADCC against antibody-bound target cells. FcRn, expressed in the placenta, allows the selective transport of maternal IgG antibodies from the mother to the developing foetus, providing passive immunity to the new-born. The engagement of Fc receptors on immune cells can also influence the balance and regulation of immune responses. It can determine the type and strength of the immune response based on the antibody isotype and Fc receptor engagement. Finally, Fc receptors, particularly on phagocytic cells, facilitate the clearance of immune complexes formed during infections, immune reactions, or autoimmunity. We offer a wide product range of research tools for investigating immunoglobulin receptors, including CD79a antibodies, CD23 antibodies, TIM 3 antibodies, EPO Receptor ELISA Kits, and TLR2 ELISA Kits. Explore our full immunoglobulin receptors product range below and discover more, for less.

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Flow Cytometry - Anti-CD79a Antibody [HM57] (PE) (A86606) - Antibodies.com
Flow Cytometry - Anti-CD79a Antibody [HM57] (A86608) - Antibodies.com
(2)
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Immunohistochemistry - Anti-CD79a Antibody [JCB117 + HM47/A9] - BSA and Azide free (A253965) - Antibodies.com
(6)
Immunohistochemistry - Anti-CD79a Antibody [JCB117 + HM47/A9] (A250785) - Antibodies.com
(6)
Immunohistochemistry - Anti-CD79a Antibody [IGA/1790R] - BSA and Azide free (A253970) - Antibodies.com
(6)
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Immunohistochemistry - Anti-CD79a Antibody [IGA/1790R] (A250790) - Antibodies.com
(6)
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Immunohistochemistry - Anti-CD79a Antibody [HM47/A9] - BSA and Azide free (A253963) - Antibodies.com
(5)
Immunohistochemistry - Anti-CD79a Antibody [HM47/A9] (A250783) - Antibodies.com
(5)
Immunohistochemistry - Anti-CD79a Antibody [HM57] - BSA and Azide free (A253969) - Antibodies.com
(5)
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Immunohistochemistry - Anti-CD79a Antibody [HM57] (A250789) - Antibodies.com
(5)
Flow Cytometry - Anti-CD79a Antibody [HM47] (PE) (A86325) - Antibodies.com
Western Blot - Anti-CD79a Antibody (A8388) - Antibodies.com
(7)
Flow Cytometry - Anti-CD79a Antibody [HM47] (PE-Cyanine 7) (A122025) - Antibodies.com
Western Blot - Anti-TLR4 Antibody (A304918) - Antibodies.com
(6)
Western Blot - Anti-TLR3 Antibody (A81091) - Antibodies.com
(7)
Flow Cytometry - Anti-CD79a Antibody [HM47] (APC) (A86321) - Antibodies.com
Western Blot - Anti-TLR4 Antibody (A14637) - Antibodies.com
(4)
Flow Cytometry - Anti-CD79a Antibody [HM47] (PerCP-Cyanine 5.5) (A121963) - Antibodies.com
Immunohistochemistry - Anti-CD79a Antibody [IGA/1688R] (A250792) - Antibodies.com
(5)
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Western Blot - Anti-CD79a Antibody [ARC51145 + ARC51147] (A309326) - Antibodies.com
(6)
Western Blot - Anti-TLR8 Antibody (A13469) - Antibodies.com
(6)
Immunohistochemistry - Anti-CD79a Antibody [SPM550] - BSA and Azide free (A253964) - Antibodies.com
(3)
Western Blot - Anti-CD79a Antibody [ARC51145] (A305911) - Antibodies.com
(5)
Western Blot - Anti-PD-L2 Antibody [PDL2/2676] - BSA and Azide free (A253570) - Antibodies.com
(5)
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Immunohistochemistry - Anti-CD79a Antibody [SPM550] (A250784) - Antibodies.com
(3)
Western Blot - Anti-TRAF7 Antibody (A14346) - Antibodies.com
(5)
Immunohistochemistry - Anti-CD79a Antibody [IGA/1688R] - BSA and Azide free (A253972) - Antibodies.com
(5)
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Flow Cytometry - Anti-CD79a Antibody [HM57] (APC) (A86604) - Antibodies.com
Western Blot - Anti-HAVCR2 Antibody (A84174)
(4)
Western Blot - Anti-CD300LD Antibody (C30557) - Antibodies.com
(3)
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Immunohistochemistry - Anti-CD79a Antibody [rIGA/764] - BSA and Azide free (A253959) - Antibodies.com
(5)
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Immunohistochemistry - Anti-CD79a Antibody [JCB117] (A250781) - Antibodies.com
(5)
Western Blot - Anti-Lck Antibody (A13934) - Antibodies.com
(5)
Western Blot - Anti-Tollip Antibody (A13955) - Antibodies.com
(3)
Western Blot - Anti-PD-L2 Antibody [PDL2/2676] (A250390) - Antibodies.com
(5)
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Western Blot - Anti-FCGR2B Antibody (A83465) - Antibodies.com
(4)
Immunohistochemistry - Anti-IL-3R beta Antibody (B0444) - Antibodies.com
(3)
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SDS-PAGE - Anti-CD79a Antibody [ZL7-4] - BSA and Azide free (A253960) - Antibodies.com
(3)
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Western Blot - Anti-Nectin 2 Antibody [ARC1665] (A308952) - Antibodies.com
(4)
Western Blot - Anti-MPIG6B Antibody (A12813) - Antibodies.com
Western Blot - Anti-Epo-R Antibody (B0917) - Antibodies.com
(3)
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Immunohistochemistry - Anti-CD79a Antibody [JCB117] - BSA and Azide free (A253961) - Antibodies.com
(5)
Immunohistochemistry - Anti-CD79a Antibody [rIGA/764] (A250779) - Antibodies.com
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