Lipases

Lipases are the class of enzymes that play crucial roles in lipid metabolism and cell signalling in animal cells by catalysing the hydrolysis of lipids, breaking down triglycerides, phospholipids, and cholesterol esters into their constituent fatty acids and glycerol. Lipases are essential for various biological processes, including energy production, lipid digestion, and the generation of lipid signalling molecules. They are a diverse group of enzymes classified based on their substrate specificity and cellular localization. The three main types of lipases are triglyceride lipases, phospholipases, and cholesterol esterases. Triglyceride lipases, including hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), hydrolyse triglycerides into free fatty acids and glycerol. Phospholipases, such as phospholipase A2 (PLA2) and phospholipase C (PLC), cleave phospholipids, releasing fatty acids and other bioactive lipid mediators. Cholesterol esterases, like hormone-sensitive lipase (HSL) and carboxyl ester lipase (CEL), break down cholesterol esters into free cholesterol.Lipases are central to energy metabolism in animal cells. During periods of increased energy demand triglycerides in adipose tissue are hydrolysed by hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL). The released free fatty acids are transported to other tissues, such as muscles, where they undergo beta-oxidation in the mitochondria to produce ATP. Lipases thereby play a key role in regulating energy balance and maintaining proper fuel utilization in the body.In the digestive system, lipases are essential for lipid digestion. Triglyceride lipases, such as pancreatic lipase, are secreted into the small intestine, where they catalyse the hydrolysis of dietary triglycerides into free fatty acids and monoglycerides. These hydrolysis products are then absorbed by enterocytes lining the small intestine and reassembled into triglycerides. The newly formed triglycerides are packaged into chylomicrons that transport lipids to other tissues via the lymphatic system.Lipases also play crucial roles in cell signalling by generating bioactive lipid molecules. Phospholipases, particularly phospholipase A2 (PLA2), catalyse the hydrolysis of phospholipids, releasing free fatty acids, such as arachidonic acid. Arachidonic acid serves as a precursor for various lipid signalling molecules, including prostaglandins, leukotrienes, and thromboxanes. These lipid mediators are involved in regulating inflammation, immune responses, and platelet aggregation, amongst other physiological processes. Lipoprotein lipase (LPL) is a critical enzyme involved in lipoprotein metabolism. LPL is present on the surface of blood vessel walls and hydrolyses triglycerides in circulating lipoprotein particles, such as chylomicrons and very-low-density lipoproteins (VLDL). This hydrolysis releases free fatty acids, which are taken up by peripheral tissues for energy or storage. LPL thus plays a key role in lipid transport and maintaining lipid homeostasis. Dysregulation or mutations in lipase enzymes can lead to lipid storage diseases, such as familial hyperlipidaemia and lipodystrophies. Familial hyperlipidaemia is characterized by elevated levels of lipids in the blood due to impaired lipoprotein lipase (LPL) activity. Lipodystrophies are a group of disorders where there is abnormal fat distribution in the body due to dysfunctional lipid metabolism. We provide a wide product catalogue of research tools for studying lipases, including Cytochrome C antibodies, Cytochrome P450 2D6 antibodies, Hormone sensitive lipase antibodies, HNF-4-alpha antibodies, and ENPP2 antibodies. Explore our full lipases product range below and discover more, for less.

Showing 1- of 465 Products
Immunohistochemistry - Anti-Cytochrome C Antibody [CYCS/3128R] (A249649) - Antibodies.com
(5)
View ProductRecombinant Antibody
Immunohistochemistry - Anti-Cytochrome C Antibody [CYCS/3128R] - BSA and Azide free (A252829) - Antibodies.com
(5)
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Western Blot - Anti-CYP17A1 Antibody (A84204) - Antibodies.com
(2)
Immunohistochemistry - Anti-Cytochrome C Antibody [rCYCS/1010] - BSA and Azide free (A252828) - Antibodies.com
(3)
View ProductRecombinant Antibody
Immunohistochemistry - Anti-Cytochrome C Antibody [7H8.2C12] (A249643) - Antibodies.com
(3)
Immunohistochemistry - Anti-Cytochrome C Antibody [SPM389] (A249644) - Antibodies.com
(4)
Immunohistochemistry - Anti-Cytochrome C Antibody [rCYCS/1010] (A249648) - Antibodies.com
(3)
View ProductRecombinant Antibody
Immunohistochemistry - Anti-Cytochrome C Antibody [7H8.2C12] - BSA and Azide free (A252823) - Antibodies.com
(3)
Immunohistochemistry - Anti-Cytochrome C Antibody [SPM389] - BSA and Azide free (A252824) - Antibodies.com
(4)
Western Blot - Anti-Cytochrome C Antibody (A88286) - Antibodies.com
(7)
Western Blot - Anti-CYP11A1 Antibody (A13608) - Antibodies.com
(7)
Immunohistochemistry - Anti-Cytochrome C Antibody [CTC05] (A249644) - Antibodies.com
Western Blot - Anti-HNF-4-alpha Antibody [ARC2794] (A307694) - Antibodies.com
(5)
Western Blot - Anti-Cytochrome P450 Reductase Antibody (A16086) - Antibodies.com
(6)
View ProductKO Validated
Immunohistochemistry - Anti-Cytochrome C Antibody [CTC05] - BSA and Azide free (A252824) - Antibodies.com
Western Blot - Anti-Cytochrome C Antibody (A12553) - Antibodies.com
(5)
View ProductKO Validated
Western Blot - Anti-CYP26A1 Antibody [ARC2126] (A305322) - Antibodies.com
(5)
Western Blot - Anti-Cytochrome P450 Reductase Antibody [ARC1981] (A306367) - Antibodies.com
(5)
Western Blot - Anti-Cytochrome P450 2E1 Antibody (A13920) - Antibodies.com
(5)
Western Blot - Anti-CYP11A1 Antibody (A90201) - Antibodies.com
(5)
Western Blot - Anti-HNF4 alpha (phospho Ser313) Antibody (A7108) - Antibodies.com
(4)
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Western Blot - Anti-PLA2G2D Antibody (A6690) - Antibodies.com
(5)
Western Blot - Anti-MGLL Antibody (A82819) - Antibodies.com
(3)
Western Blot - Anti-PNPLA2 Antibody (A83688) - Antibodies.com
(2)
Western Blot - Anti-Cytochrome P450 2S1 Antibody (C12271) - Antibodies.com
(4)
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Western Blot - Anti-Cytochrome c-type Heme Lyase Antibody (C12123) - Antibodies.com
(4)
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Immunohistochemistry - Anti-CYP26B1 Antibody (A84266)
(4)
Western Blot - Anti-CPA6 Antibody (A89961) - Antibodies.com
(4)
Western Blot - Anti-Cytochrome P450 1A2 Antibody (A17132) - Antibodies.com
(4)
Western Blot - Anti-HSL (phospho Ser552) Antibody (A0437) - Antibodies.com
(3)
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Western Blot - Anti-Cytochrome P450 Reductase Antibody (A305022) - Antibodies.com
(3)
Western Blot - Anti-HSL (phospho Ser855 + Ser554) Antibody (A0074) - Antibodies.com
(3)
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Immunohistochemistry - Anti-Cytochrome P450 2E1 Antibody (C12267) - Antibodies.com
(3)
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Western Blot - Anti-Cytochrome c Antibody (C0170) - Antibodies.com
(3)
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Western Blot - Anti-Cytochrome P450 2J2 Antibody (C12269) - Antibodies.com
(4)
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Western Blot - Anti-CYP24A1 Antibody (A13669) - Antibodies.com
(4)
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Western Blot - Anti-Cytochrome C Antibody [ARC1153] (A307346) - Antibodies.com
(4)
View ProductKO Validated
Western Blot - Anti-CYP2D6 Antibody [ARC1635] (A308397) - Antibodies.com
(3)
Western Blot - Anti-PNPLA3 Antibody (A82487) - Antibodies.com
(3)
Western Blot - Anti-HSL Antibody (B0437) - Antibodies.com
(3)
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SDS-PAGE - Anti-Cytochrome C Antibody [6H2.B4] (A249642) - Antibodies.com
(3)
Western Blot - Anti-HNF4A Antibody (A83160) - Antibodies.com
(3)
SDS-PAGE - Anti-Cytochrome P450 3A1 Antibody [P6] - BSA and Azide free (A254046) - Antibodies.com
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Western Blot - Anti-Cytochrome P450 26A1 Antibody (C12254) - Antibodies.com
(3)
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Immunohistochemistry - Anti-Cytochrome C Antibody [CYCS/1010] (A249645) - Antibodies.com
(4)
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Western Blot - Anti-PLD2 (phospho Tyr169) Antibody (A8400) - Antibodies.com
(2)
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Showing 1-50 of 465 products

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