Cell Adhesion Proteins

Cell adhesion plays critical roles in the development, function, and plasticity of the nervous system. It involves the interactions between cells and their surrounding extracellular matrix, with neighbouring cells, or with other components of the neural environment. Cell adhesion influences various neurobiological processes, including neuronal migration, synapse formation, axonal guidance, and neural circuit assembly, all essential for the proper functioning of the brain and the establishment of neural connectivity. Underpinning cell adhesion are cell adhesion molecules (CAMs), which mediate cell-cell and cell-extracellular matrix (ECM) interactions. CAMs are transmembrane proteins and responsible for adhering cells together, facilitating communication between them, and influencing their behaviour during development and adulthood. CAMs are classified into several families based on their structure and function. Some of the most prominent CAM families in neuroscience include cadherins, integrins, immunoglobulin superfamily (IgSF) proteins, and selectins. Cadherins are calcium-dependent cell adhesion molecules that are critical for establishing and maintaining the structural integrity of tissues and organs. In the nervous system they are essential for guiding migrating neurons to their final destinations during brain development. They also contribute to synapse formation and synaptic plasticity, the ability of synapses to change their strength in response to increased activity. Integrins are primarily responsible for mediating interactions between cells and the ECM and in the nervous system are involved in axon growth and guidance, synaptic plasticity, and neuronal migration. They provide an important link between the ECM and the intracellular cytoskeleton, allowing cells to sense and respond to their environment. The immunoglobulin superfamily (IgSF) comprises a large group of cell adhesion molecules such as NCAM (neural cell adhesion molecule) and L1 (L1 cell adhesion molecule) that are essential for axon guidance, neurite outgrowth, and synaptic plasticity. They also contribute to neural cell migration and play a role in the formation and maintenance of neural circuits. Selectins meanwhile are a family of cell adhesion molecules that generally mediate interactions between cells and the endothelium, the inner lining of blood vessels. They may also play a role in neuroinflammation and the migration of immune cells into the brain. Throughout development and in response to neural activity and environmental cues, the expression and function of CAMs can change, influencing neural connectivity and synaptic strength. As such, dysregulation of cell adhesion processes has been implicated in various neurological disorders. For example, alterations in cadherin-mediated adhesion are associated with neurodevelopmental disorders, such as autism spectrum disorders (ASD) and intellectual disabilities. In these conditions, mutations in cadherin genes or changes in their expression may disrupt neural circuit formation and function, potentially contributing to the observed behavioural and cognitive impairments. Integrins have similarly been linked to neurological diseases. In multiple sclerosis (MS), an autoimmune disorder that affects the central nervous system, integrins play a role in the migration of immune cells into the brain, leading to inflammation and damage to myelin, the protective coating of nerve fibres. Finally, the dysfunction of CAMs, particularly those of the IgSF family, has been implicated in neurodegenerative diseases such as Alzheimer's disease. We offer a comprehensive product catalogue of research tools for investigating cell adhesion proteins, including NCAM antibodies, GFAP antibodies, Prostate Specific Antigen antibodies, Galectin 3 ELISA Kits, and Prostate Specific Antigen ELISA Kits. Explore our full cell adhesion proteins product range below and discover more, for less. Alternatively, you can explore our ECM Proteins, Cytoskeletal Proteins, and Membrane Proteins product ranges.

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Immunofluorescence - Anti-GFAP Antibody (A85419) - Antibodies.com
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Immunofluorescence - Anti-GFAP Antibody (A85307) - Antibodies.com
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Immunocytochemistry - Anti-beta III Tubulin Antibody [TU-20] (A86689) - Antibodies.com
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ELISA - Anti-GFAP Antibody (A83720)
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Immunohistochemistry - Anti-Laminin Antibody (A85395) - Antibodies.com
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Immunofluorescence - Anti-GFAP Antibody - Antibodies.com (A104314)
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Immunofluorescence - Anti-Peripherin Antibody (A85430) - Antibodies.com
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Immunofluorescence - Anti-MBP Antibody (A85322) - Antibodies.com
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Immunofluorescence - Anti-NF-M Antibody (A85323) - Antibodies.com
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Standard Curve - Human Prostate Specific Antigen ELISA Kit (EL10005) - Antibodies.com
Western Blot - Anti-Galectin 3 Antibody (C0203) - Antibodies.com
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Immunofluorescence - Anti-MBP Antibody (A85321) - Antibodies.com
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Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4273] (A249286) - Antibodies.com
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Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4273] - BSA and Azide free (A252466) - Antibodies.com
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Immunofluorescence - Anti-NF-M Antibody (A85324) - Antibodies.com
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Western Blot - Anti-GFAP Antibody (A12563) - Antibodies.com
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Immunofluorescence - Anti-GFAP Antibody [5C10] (A85422) - Antibodies.com
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Immunofluorescence - Anti-Nestin Antibody (A85293) - Antibodies.com
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Immunohistochemistry - Anti-Neurofilament Heavy Polypeptide Antibody [NE14] (A249491) - Antibodies.com
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Western Blot - Anti-GFAP Antibody [GA-5] - BSA and Azide free (A251887) - Antibodies.com
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Immunohistochemistry - Anti-Neurofilament Heavy Polypeptide Antibody [NE14] - BSA and Azide free (A252671) - Antibodies.com
(5)
Immunohistochemistry - Anti-Tenascin Antibody [T2H5] (A86775) - Antibodies.com
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Western Blot - Anti-Cathepsin D Antibody (AB0043) - Antibodies.com
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Immunohistochemistry - Anti-67kDa Laminin Receptor Antibody [RPSA/2699] (A249224) - Antibodies.com
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Immunohistochemistry - Anti-Myelin Basic Protein Antibody (V0099) - Antibodies.com
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Immunohistochemistry - Anti-67kDa Laminin Receptor Antibody [RPSA/2699] - BSA and Azide free (A252404) - Antibodies.com
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Immunofluorescence - Anti-Alpha-Internexin Antibody (A85441) - Antibodies.com
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Immunofluorescence - Anti-MBP Antibody (A85329) - Antibodies.com
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Immunohistochemistry - Anti-Reelin Antibody [RELN/4498] (A277582) - Antibodies.com
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Western Blot - Anti-GFAP Antibody [GA-5] (A248705) - Antibodies.com
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Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4275] (A249288) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [GA-5 + ASTRO/789] (A248708) - Antibodies.com
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Immunofluorescence - Anti-NF-M Antibody (A85325) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [SPM248] - BSA and Azide free (A251888) - Antibodies.com
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Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4275] - BSA and Azide free (A252468) - Antibodies.com
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Western Blot - Anti-Collagen II Antibody (C0155) - Antibodies.com
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Immunohistochemistry - Anti-Neurofilament Heavy Polypeptide Antibody [NF421] (A249487) - Antibodies.com
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Immunofluorescence - Anti-Peripherin Antibody (A85433) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [SPM248] (A248706) - Antibodies.com
(4)
Immunohistochemistry - Anti-Neurofilament Heavy Polypeptide Antibody [NF421] - BSA and Azide free (A252667) - Antibodies.com
(6)
Western Blot - Anti-GFAP Antibody [ARC0206] (A307282) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [GA-5 + ASTRO/789] - BSA and Azide free (A251890) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [rASTRO/789] - BSA and Azide free (A251893) - Antibodies.com
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View ProductRecombinant Antibody
Western Blot - Anti-Stathmin 1 Antibody [ARC0989] (A306459) - Antibodies.com
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Western Blot - Anti-Galectin 3 Antibody (A306858) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [SPM507] (A248706) - Antibodies.com
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Immunohistochemistry - Anti-Alpha-Internexin Antibody (A85448) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [ASTRO/789] (A248708) - Antibodies.com
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Western Blot - Anti-DCX Antibody (A83146) - Antibodies.com
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