Membrane Proteins

Membrane proteins play many critical roles in neuroscience, facilitating various processes essential for neuronal communication and brain function. These proteins are embedded within the lipid bilayer of cell membranes and function as receptors, channels, and transporters. By mediating the flow of ions and molecules, they control neurotransmission, signal transduction, and neuronal homeostasis. Neurotransmission is the fundamental process through which neurons communicate with one another. Ion channels within the neuronal membrane play a central role in this process. These channels control the flow of ions (e.g., sodium, potassium, calcium) across the neuronal membrane, generating electrical signals known as action potentials. For example, ligand-gated ion channels, such as the glutamate receptors, are crucial for fast excitatory synaptic transmission, whilst G-protein-coupled receptors modulate slower synaptic responses through second messenger systems. Dysfunction of these membrane proteins can lead to neurological conditions including epilepsy and schizophrenia. Another vital role of membrane proteins in neuroscience is the regulation of neurotransmitter concentrations in the synaptic cleft. Transporter proteins actively remove excess neurotransmitters from the extracellular space, terminating signal transmission and preventing overstimulation. For example, the serotonin transporter is essential for the reuptake of serotonin, an important neurotransmitter involved in mood regulation. Malfunctions in these transporters have been associated with mood disorders such as depression and anxiety. Synaptic plasticity, the ability of synapses to strengthen or weaken over time, is thought to be the foundation of learning and memory. Membrane receptors such as the NMDA (N-methyl-D-aspartate) receptor and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor are critical in regulating synaptic plasticity. The NMDA receptor is required for both long-term potentiation (LTP) and long-term depression (LTD), two processes that underlie memory formation and storage. By allowing calcium influx into neurons, these receptors trigger intracellular signalling cascades that modify synaptic strength. Action potentials are the electrical signals that neurons use to communicate over long distances and voltage-gated ion channels in the neuronal membrane are key players in their initiation and propagation. For example, voltage-gated sodium channels open upon depolarization, leading to rapid sodium influx and the generation of an action potential. Conversely, potassium channels repolarize the neuron and function in terminating the action potential. Disruptions in the function of these channels can correspondingly lead to various neurological disorders such as channelopathies and nerve conduction abnormalities. As might be anticipated, dysfunction of membrane proteins in the brain is implicated in a wide range of neurological disorders. For example, misfolded proteins, such as the amyloid-beta protein in Alzheimer's disease, can disrupt synaptic function and lead to cognitive decline. Additionally, mutations in ion channels have been linked to disorders like epilepsy, migraine, and ataxia. Thus, understanding the roles of membrane proteins in these conditions has paved the way for the development of targeted therapies, aiming to modulate their function and alleviate symptoms. We offer a wide product range of research reagents for investigating neuronal membrane proteins, including Syndecan-1 antibodies, Myelin Basic Protein antibodies, Cathepsin D antibodies, Cathepsin D ELISA Kits, and Cathepsin L ELISA Kits. Explore our full neuronal membrane proteins product range below and discover more, for less.

Showing 1- of 392 Products
Immunofluorescence - Anti-MBP Antibody (A85322) - Antibodies.com
(4)
View Product10µl Trial Size
Immunofluorescence - Anti-MBP Antibody (A85321) - Antibodies.com
(3)
View Product10µl Trial Size
Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4273] (A249286) - Antibodies.com
(4)
Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4273] - BSA and Azide free (A252466) - Antibodies.com
(4)
Western Blot - Anti-Cathepsin D Antibody (AB0043) - Antibodies.com
(5)
Immunohistochemistry - Anti-Myelin Basic Protein Antibody (V0099) - Antibodies.com
(14)
View Product10µl Trial Size
Immunofluorescence - Anti-MBP Antibody (A85329) - Antibodies.com
(4)
View Product10µl Trial Size
Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4275] - BSA and Azide free (A252468) - Antibodies.com
(4)
Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4275] (A249288) - Antibodies.com
(4)
Antibodies.com Image Placeholder - Discover more for less
Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4274] - BSA and Azide free (A252467) - Antibodies.com
(4)
Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4274] (A249287) - Antibodies.com
(4)
Western Blot - Anti-Cathepsin G Antibody (A89125) - Antibodies.com
(5)
Western Blot - Anti-Cathepsin B Antibody (A12726) - Antibodies.com
(7)
Western Blot - Anti-Cathepsin B Antibody (R12-2057) - Antibodies.com
(5)
View Product10µg Trial Size
Western Blot - Anti-Cathepsin G Antibody (A9732) - Antibodies.com
(6)
Antibodies.com Image Placeholder - Discover more for less
Antibodies.com Image Placeholder - Discover more for less
Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4272] - BSA and Azide free (A252462) - Antibodies.com
(5)
Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4272] (A249282) - Antibodies.com
(5)
Western Blot - Anti-Myelin Basic Protein Antibody (A13581) - Antibodies.com
(6)
Validation Data - Anti-Myelin Basic Protein Antibody [MBP101] - BSA and Azide free (A304206)
Western Blot - Anti-CDH9 Antibody (C12107) - Antibodies.com
(4)
View Product10µg Trial Size
Western Blot - Anti-BIG-2 Antibody [ARC2761] (A305779) - Antibodies.com
(6)
Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4271] - BSA and Azide free (A252461) - Antibodies.com
(4)
Immunohistochemistry - Anti-Myelin Basic Protein Antibody [MBP/4271] (A249281) - Antibodies.com
(4)
Western Blot - Anti-Neuroligin 4 Antibody (A14578) - Antibodies.com
(2)
Western Blot - Anti-CDH8 Antibody (C12106) - Antibodies.com
(4)
View Product10µg Trial Size
Antibodies.com Image Placeholder - Discover more for less
Western Blot - Anti-Myelin PLP Antibody (A306001) - Antibodies.com
(5)
Immunohistochemistry - Anti-Cathepsin D Antibody [CTSD/3276] (A248308) - Antibodies.com
(5)
View ProductMonospecific Antibody
Immunocytochemistry/Immunofluorescence - Anti-VGluT1 Antibody [S28-9] (A304823) - Antibodies.com
(4)
Western Blot - Anti-Cathepsin D Antibody (A89998) - Antibodies.com
(4)
Immunofluorescence - Anti-Myelin Basic Protein Antibody (A270546) - Antibodies.com
(2)
View Product10µl Trial Size
Western Blot - Anti-AMIGO1 Antibody [S86-36] (A305013) - Antibodies.com
(3)
Immunohistochemistry - Anti-Cathepsin D Antibody [CTSD/4497] (A277569) - Antibodies.com
(6)
View ProductMonospecific Antibody
Immunohistochemistry - Anti-Cathepsin D Antibody [CTSD/3082] - BSA and Azide free (A251487) - Antibodies.com
(6)
View ProductMonospecific Antibody
Immunohistochemistry - Anti-Cathepsin D Antibody [CTSD/3082] (A248305) - Antibodies.com
(6)
View ProductMonospecific Antibody
Western Blot - Anti-PVRL1 Antibody (C30415) - Antibodies.com
(3)
View Product10µg Trial Size
Immunohistochemistry - Anti-Cathepsin D Antibody [CTSD/4497] - BSA and Azide free (A278157) - Antibodies.com
(6)
View ProductMonospecific Antibody
Immunohistochemistry - Anti-Cathepsin D Antibody [CTSD/3276] - BSA and Azide free (A251490) - Antibodies.com
(5)
View ProductMonospecific Antibody
Western Blot - Anti-Syndecan-1 Antibody [ARC0918] (A308330) - Antibodies.com
(3)
Western Blot - Anti-SPRR3 Antibody (A80925) - Antibodies.com
(4)
Immunohistochemistry - Anti-Myelin Basic Protein (phospho Thr98) Antibody [MBP/4276] - BSA and Azide free (A252463) - Antibodies.com
(4)
Immunohistochemistry - Anti-Myelin Basic Protein (phospho Thr98) Antibody [MBP/4276] (A249283) - Antibodies.com
(4)
Western Blot - Anti-SCRIB Antibody (A121159)
(2)
Western Blot - Anti-PMP22 Antibody (C0306) - Antibodies.com
(2)
View Product10µg Trial Size
Western Blot - Anti-Syndecan-1 Antibody (A8893) - Antibodies.com
(3)
Immunohistochemistry - Anti-NXPH1 Antibody (C16915) - Antibodies.com
(2)
View Product10µg Trial Size
Immunohistochemistry - Anti-Myelin PLP Antibody [PLP1/4259] - BSA and Azide free (A252817) - Antibodies.com
(2)

Showing 1-50 of 392 products

Search Filters Main Menu Contact Us 0Checkout
Top