Neurogenesis refers to the process of generating new neurons in the brain, particularly in regions known as neurogenic niches. Neurogenesis was once believed to be limited to early development, but research has shown that neurogenesis continues throughout life in specific brain regions. Neurogenesis therefore plays a crucial role in brain plasticity, learning, memory, and recovery from brain injuries. The hippocampus is involved in learning and memory and one of the most well-studied areas for adult neurogenesis. In the dentate gyrus, a region within the hippocampus, neural stem cells give rise to new neurons throughout adulthood. Within the neurogenic niche are located neural stem cells called radial glia-like cells or type 1 cells. These stem cells can self-renew and differentiate into new neurons. Neural stem cells give rise to intermediate progenitor cells (type 2 cells), which are more committed to becoming neurons. The intermediate progenitor cells mature into neuroblasts (type 3 cells), which are migratory immature neurons. These neuroblasts migrate from the neurogenic niche to the granule cell layer of the dentate gyrus then undergo a maturation process and integrate into existing hippocampal circuits. They then form synapses and become functional neurons contributing to various hippocampus-dependent cognitive functions. Neurogenesis in the hippocampus is believed to play a crucial role in learning and memory. For example, studies in animal models have shown that enhanced neurogenesis is associated with improved performance in spatial learning and memory tasks. The olfactory bulb is responsible for processing olfactory information (sense of smell). In the subventricular zone (SVZ) lining the lateral ventricles neural stem cells give rise to neuroblasts that migrate to the olfactory bulb, where they differentiate into interneurons called granule cells and periglomerular cells. These new neurons play a role in odour processing and olfactory discrimination. Neurogenesis is influenced by various environmental factors. Exercise, for example, has been shown to increase neurogenesis in the hippocampus and improve cognitive function. Neurogenesis is also involved in brain repair and recovery from injuries. After brain injuries, such as stroke or trauma, neurogenesis is triggered to replace damaged neurons and restore brain function. However, the extent of this repair process varies depending on the severity and location of the injury. Neurogenesis is most active during early development, contributing to the rapid growth and wiring complexity of the brain. In the adult brain, neurogenesis declines with age, particularly in the hippocampus. This decline is associated with age-related cognitive decline and may contribute to certain neurodegenerative diseases. The process of neurogenesis is sustained by neural stem cells, which have the capacity to self-renew and differentiate into different types of neurons and glial cells. In the adult brain, neural stem cells reside in specific niches, such as the subgranular zone of the dentate gyrus in the hippocampus and the SVZ. The discovery of neurogenesis in the adult brain has generated interest in its therapeutic potential. For example, researchers are exploring ways to enhance neurogenesis as a potential treatment for neurodegenerative diseases, stroke, and other neurological disorders. We offer a large product catalogue of research reagents for investigating neurogenesis, including Vimentin antibodies, beta Catenin antibodies, Ki67 antibodies, FOXO1A ELISA Kits, and beta Catenin ELISA Kits. Explore our full neurogenesis product range below and discover more, for less.