The Notch pathway is a critical signalling system that plays crucial roles in various aspects of neuroscience, including in brain development, neural stem cell maintenance, synaptic plasticity, and neurodegenerative diseases. This conserved pathway regulates cell fate decisions and communication between neighbouring cells, influencing neural development and function throughout life. The Notch pathway is named after the receptor protein Notch, which spans the cell membrane and interacts with ligands from neighbouring cells. When a ligand binds to the Notch receptor, it triggers a series of proteolytic cleavage events, leading to the release of the Notch intracellular domain (NICD). NICD translocates to the nucleus and forms a transcriptional complex, regulating the expression of target genes that control cell fate and function. During embryonic brain development, the Notch pathway plays an important role in guiding the differentiation and maturation of neural progenitor cells. Notch signalling maintains neural stem cells, inhibiting their premature differentiation and promoting self-renewal. As a result, Notch ensures a balanced production of neurons and glial cells, critical for proper brain development and the establishment of functional neural circuits.In the adult brain, the Notch pathway continues to regulate neurogenesis and neural stem cell activity in neurogenic niches. For example, the subventricular zone (SVZ) and the dentate gyrus of the hippocampus are regions where neurogenesis persists throughout life. Notch signalling influences the proliferation and differentiation of neural stem cells in these areas, contributing to brain plasticity and potentially aiding in repair after injury or in neurological disorders. Notch signalling also plays a role in synaptic plasticity, which is essential for learning and memory processes. The pathway regulates the formation and strength of synapses by modulating the expression of synaptic proteins such as synaptotagmin, a calcium-binding protein present in synaptic vesicles that plays a critical role in neurotransmitter release during synaptic transmission, and PSD-95, a scaffolding protein located in the postsynaptic density of excitatory synapses involved in anchoring and clustering glutamate receptors and other signalling molecules, contributing to synapse development and plasticity. Moreover, the Notch pathway is involved in neurological disorders and diseases. For instance, dysregulated Notch signalling has been linked to Alzheimer's disease (AD). Notch signalling also interacts with components of the amyloid precursor protein (APP) processing pathway, influencing the generation of amyloid-beta (Aβ) plaques, a hallmark of AD pathology, and may impact upon tau protein phosphorylation, another crucial factor in AD pathology. Finally, the Notch pathway has implications in glioblastoma, an aggressive form of brain cancer. Notch signalling has been shown to contribute to the initiation and maintenance of glioblastoma stem cells (GSCs), a subpopulation of cells within glioblastomas that possess stem cell-like properties and are thought to drive tumour growth and resistance to therapy. The Notch pathway also promotes cell proliferation and inhibits apoptosis (programmed cell death) in glioblastoma cells. Activation of Notch signalling leads to the upregulation of genes that promote cell cycle progression, which contributes to the uncontrolled growth of tumour cells. We offer a comprehensive product catalogue of research tools for studying the Notch signaling pathway, including GSK3 beta antibodies, Notch1 antibodies, Presenilin 1 antibodies, NOTCH3 antibodies, and SIAH1 antibodies. Explore our full Notch signaling pathway product range below and discover more, for less.