Hematopoietic progenitors are a diverse group of cells in the bone marrow that give rise to the various blood cell lineages. These progenitors undergo differentiation into specific blood cell types under the influence of various intracellular proteins. Understanding the important intracellular proteins involved in this regulation of hematopoietic progenitors is crucial for comprehending haematopoiesis, blood cell development, and potential therapeutic interventions. GATA-1 is a transcription factor that plays a central role in the development of erythroid cells, which give rise to red blood cells. GATA-1 regulates the expression of genes involved in erythropoiesis, including globin genes, and is essential for the maturation of red blood cell precursors. GATA-2, another member of the GATA family of transcription factors, is crucial for the development of both erythroid and myeloid lineages. It is involved in maintaining the multipotency of hematopoietic stem and progenitor cells (HSPCs) and is a key regulator of hematopoietic stem cell self-renewal. PU.1 is an additional transcription factor critical for the development of myeloid cells, including granulocytes, monocytes, and dendritic cells. It regulates genes involved in myeloid differentiation and is essential for the commitment of hematopoietic progenitors to the myeloid lineage. Similarly, the transcription factor RUNX1 also plays a pivotal role in haematopoiesis being essential for the development of various blood cell lineages, including red blood cells, platelets, and T lymphocytes. Mutations in RUNX1 are also associated with several blood disorders, including acute myeloid leukaemia (AML). Within hematopoietic progenitors Notch receptors and their ligands are involved in cell-fate decisions. Activation of Notch signalling can influence the differentiation of progenitors into various cell types, including T lymphocytes and dendritic cells. FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that regulates the proliferation and survival of hematopoietic progenitors. Mutations in FLT3 are also associated with acute myeloid leukaemia (AML), making it an important therapeutic target in leukaemia. The Wnt/β-catenin signalling pathway is involved in maintaining the self-renewal capacity of HSPCs. It regulates hematopoietic stem cell quiescence and proliferation, and dysregulation of this pathway can contribute to haematological malignancies. Intracellular proteins of the BCL-2 family, such as BCL-2, BCL-XL, and MCL-1, are critical regulators of apoptosis (cell death) in hematopoietic progenitors. They control the balance between cell survival and apoptosis, influencing the number and longevity of blood cells. Signal transducer and activator of transcription (STAT) proteins are important mediators of cytokine signalling in hematopoietic progenitors. They transduce signals from cytokine receptors, leading to changes in gene expression and cell fate decisions. Finally, c-MYC is an oncogenic transcription factor that can drive cell proliferation when dysregulated. It plays a role in promoting the expansion of hematopoietic progenitors and is often implicated in leukaemia and lymphoma. We provide a comprehensive product catalogue of research reagents for studying HPCs related intracellular molecules, including ALDH1A1 antibodies, ERG antibodies, Bmi1 antibodies, Erythropoietin (EPO) ELISA Kits, and GATA1 ELISA Kits. Explore our full HPCs related intracellular molecules product range below and discover more, for less.