Glial Restricted Lineage

Glial-restricted progenitor cells (GRPs) are a type of precursor cell in the central nervous system (CNS) committed to the glial cell lineage, and generate glial cells, including astrocytes and oligodendrocytes. They do not have the potential to differentiate into neurons, unlike some other neural progenitor cells. GRPs can differentiate into various types of glial cells. They can give rise to astrocytes, which provide support and maintenance functions for neurons, as well as oligodendrocytes, which are responsible for producing myelin to insulate axons in the CNS. The expression of specific transcription factors within GRPs can predispose them toward a particular glial lineage. For example, the transcription factor Olig2 is known to promote oligodendrocyte differentiation, whilst transcription factors such as NFIA and NFIB are associated with astrocyte development. The presence of different growth factors and cytokines in the microenvironment of GRPs can also strongly influence their fate. For example, the presence of Platelet-Derived Growth Factor (PDGF) and Fibroblast Growth Factor (FGF) tends to promote oligodendrocyte differentiation, whilst Ciliary Neurotrophic Factor (CNTF) and Leukaemia Inhibitory Factor (LIF) and cytokines like Interleukin-6 (IL-6) promote astrocyte differentiation. Notch signalling also plays a role in glial fate determination. Activation of the Notch pathway can promote astrocyte differentiation, whilst inhibition can favour oligodendrocyte differentiation. The types and states of neighbouring cells can also strongly influence GRP fate. Astrocytes themselves can release factors that promote astrocytic differentiation, whilst oligodendrocytes or their precursor cells can release factors favouring oligodendrocytic differentiation. GRPs are typically found in specific regions of the CNS, including the spinal cord and certain areas of the brain. They are generally not as widespread as other neural progenitor cells, and their distribution is more limited. One of the primary functions of GRPs is to generate oligodendrocytes, cells essential for the production and maintenance of the myelin sheath around neuronal axons. This myelin sheath helps facilitate efficient nerve signal transmission. GRPs thus play a crucial role in CNS repair and regeneration. When there is damage to the CNS, GRPs can proliferate and differentiate into the necessary glial cells to replace damaged or lost tissue. Dysregulation or dysfunction of GRPs can have significant implications for CNS disorders, particularly those involving demyelination, such as multiple sclerosis. Loss of myelin due to a reduction in oligodendrocyte production can lead to drastically impaired neural function. Thus, glial-restricted progenitor cells are precursor cells in the CNS committed to the glial cell lineage. They primarily give rise to astrocytes and oligodendrocytes, thereby playing a prominent role in maintaining and repairing the CNS, especially in terms of myelin production and glial support for neurons. Their limited potential for neuronal differentiation distinguishes them apart from other neural progenitor cells in the CNS. We provide a large product range of research reagents for studying glial restricted progenitor cells, including GFAP antibodies, S100 beta antibodies, FGFR3 antibodies, CNTF ELISA Kits, and GFAP ELISA Kits. Explore our full glial restricted progenitor cells product range below and discover more, for less. Alternatively, you can explore our Astrocyte and Glial Progenitors product ranges.

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Immunofluorescence - Anti-GFAP Antibody (A85419) - Antibodies.com
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Immunofluorescence - Anti-GFAP Antibody (A85307) - Antibodies.com
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ELISA - Anti-GFAP Antibody (A83720)
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Immunofluorescence - Anti-GFAP Antibody - Antibodies.com (A104314)
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Western Blot - Anti-GFAP Antibody (A12563) - Antibodies.com
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Immunofluorescence - Anti-GFAP Antibody [5C10] (A85422) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [S100B/1012] - BSA and Azide free (A253116) - Antibodies.com
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Western Blot - Anti-GFAP Antibody [GA-5] - BSA and Azide free (A251887) - Antibodies.com
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Western Blot - Anti-GFAP Antibody [GA-5] (A248705) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [SPM248] - BSA and Azide free (A251888) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [GA-5 + ASTRO/789] (A248708) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [S100B/1012] (A249936) - Antibodies.com
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Western Blot - Anti-GFAP Antibody [ARC0206] (A307282) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [SPM248] (A248706) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [GA-5 + ASTRO/789] - BSA and Azide free (A251890) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [SPM507] (A248706) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [ASTRO/789] (A248708) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [SPM507] - BSA and Azide free (A251888) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [ASTRO/789] - BSA and Azide free (A251890) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [rASTRO/789] (A248711) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [rASTRO/789] - BSA and Azide free (A251893) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [4C4.9] - BSA and Azide free (A253114) - Antibodies.com
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Western Blot - Anti-GFAP Antibody (A90190) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [4C4.9] (A249934) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [rS100B/1896] (A249938) - Antibodies.com
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SDS-PAGE - Anti-S100 beta Antibody [S100B/4153] (A277783) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [S100B/1706R] - BSA and Azide free (A253120) - Antibodies.com
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SDS-PAGE - Anti-S100 beta Antibody [S100B/4153] - BSA and Azide free (A278371) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [ASTRO/1974R] (A248712) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [ASTRO/1974R] - BSA and Azide free (A251894) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [4C4.9 + S100B/1012] (A249937) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [SPM354] - BSA and Azide free (A253114) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [4C4.9 + S100B/1012] - BSA and Azide free (A253117) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [rS100B/1896] - BSA and Azide free (A253118) - Antibodies.com
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Western Blot - Anti-S100 beta Antibody (A17137) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [SPM354] (A249934) - Antibodies.com
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Immunohistochemistry - Anti-S100 beta Antibody [S100B/1706R] (A249940) - Antibodies.com
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Western Blot - Anti-S100 beta Antibody [ARC50351] (A307742) - Antibodies.com
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Western Blot - Anti-FGFR3 Antibody (C0192) - Antibodies.com
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Western Blot - Anti-FGFR3 Antibody (A8397) - Antibodies.com
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Western Blot - Anti-GFAP Antibody (B1205) - Antibodies.com
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Immunofluorescence - Anti-GFAP Antibody [3E10] (A270551) - Antibodies.com
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Western Blot - Anti-GFAP Antibody [S206A-8] (A304711) - Antibodies.com
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Western Blot - Anti-GFAP Antibody [S206B-9] (A304763) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [GF-01] (A85506) - Antibodies.com
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Immunohistochemistry - Anti-GFAP Antibody [GFAP/4450] - BSA and Azide free (A278215) - Antibodies.com
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