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Anti-Profilin-1 Antibody

Rabbit polyclonal antibody to Profilin-1 from ABclonal (A0639).
Name: Anti-Profilin-1 Antibody
Description: Rabbit polyclonal antibody to Profilin-1.
Applications: WB
Dilutions: WB: 1:500 - 1:1000.
Reactivity: Human
Immunogen: A synthetic peptide of human PFN1.
Protein Length: 140
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Tissue Specificity: Expressed in epididymis (at protein level).
Involvement in Disease: Amyotrophic lateral sclerosis 18: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Sequence Similarities: Belongs to the profilin family.
Post-Translational Modification: Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.
Cellular Location: Cytoplasm > Cytoskeleton.
UniProt: P07737
Gene ID: 5216
Synonyms: Actin binding protein Antibody
ALS18 Antibody
Epididymis tissue protein Li 184a Antibody
OTTHUMP00000125244 Antibody
Pfn Antibody
PFN 1 Antibody
PFN1 Antibody
PROF1_HUMAN Antibody
Profilin 1 Antibody
Profilin I Antibody
Profilin1 Antibody
ProfilinI Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of HeLa cells, using PFN1 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Total Citations (2)
Description: Rabbit polyclonal antibody to PFN1
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human PFN1.

£220 – £366

Description: Rabbit polyclonal antibody to PFN1
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human PFN1.


Description: Rabbit polyclonal antibody to PFN1.
Application: WB, IHC
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Description: Rabbit polyclonal antibody to PFN1
Application: E, WB
Host: Rabbit
Reactivity: Human
Immunogen: Fusion protein corresponding to a region derived from 2-140 amino acids of human profilin 1

£180 – £234

Please Note: Anti-Profilin-1 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0639
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe