Anti-SA2 (STAG2) Antibody
Rat monoclonal (KT76) antibody to SA2 (STAG2) from Absea Biotechnology (160408C11).
|Name:||Anti-SA2 (STAG2) Antibody|
|Description:||Rat monoclonal (KT76) antibody to SA2 (STAG2).|
|Immunogen:||Recombinant mouse STAG2 (aa1073 - aa1232).|
|Amino Acid Start:||1073|
|Amino Acid End:||1232|
|Concentration:||1 mg/ml in PBS containing 0.09% sodium azide as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
|Function:||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity).|
|Sequence Similarities:||Belongs to the SCC3 family.|
|Post-Translational Modification:||Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).|
|Cellular Location:||Nucleus. Chromosome. Chromosome > Centromere.
Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex (By similarity).
Cohesin Subunit SA 2 Antibody
Cohesin subunit SA-2 Antibody
SA 2 Antibody
SCC3 homolog 2 Antibody
STAG 2 Antibody
Stromal antigen 2 Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
Please Note: Anti-SA2 (STAG2) Antibody is for research use only. It is not intended for diagnostic of therapeutic use.