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Anti-Tuberin/TSC2 Antibody

Rabbit polyclonal antibody to Tuberin/TSC2 from ABclonal (A0491).
Name: Anti-Tuberin/TSC2 Antibody
Description: Rabbit polyclonal antibody to Tuberin/TSC2.
Applications: WB, IHC, IF
Dilutions: WB: 1:200 - 1:500, IHC: 1:50 - 1:100, IF: 1:50 - 1:100.
Reactivity: Human
Immunogen: A synthetic peptide of human TSC2.
Protein Length: 1807
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Tissue Specificity: Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
Involvement in Disease: Tuberous sclerosis 2: An autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. It is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination). Clinical manifestations include epilepsy, learning difficulties, behavioral problems, and skin lesions. Seizures can be intractable and premature death can occur from a variety of disease-associated causes.

Lymphangioleiomyomatosis: Progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex.
Post-Translational Modification: Phosphorylation at Ser-1387, Ser-1418 or Ser-1420 does not affect interaction with TSC1. Phosphorylation at Ser-939 and Thr-1462 by PKB/AKT1 is induced by growth factor stimulation. Phosphorylation by AMPK activates it and leads to negatively regulates the mTORC1 complex. Phosphorylated at Ser-1798 by RPS6KA1; phosphorylation inhibits TSC2 ability to suppress mTORC1 signaling. Phosphorylated by DAPK1.
Cellular Location: Cytoplasm. Membrane.

At steady state found in association with membranes.
UniProt: P49815
Gene ID: 7249
Synonyms: FLJ43106 Antibody
LAM Antibody
OTTHUMP00000158940 Antibody
OTTHUMP00000198394 Antibody
OTTHUMP00000198395 Antibody
PPP1R160 Antibody
Protein phosphatase 1, regulatory subunit 160 Antibody
TSC2_HUMAN Antibody
TSC4 Antibody
TSC4 gene, formerly Antibody
TSC4, formerly Antibody
Tuberin Antibody
Tuberous sclerosis 2 Antibody
Tuberous sclerosis 2 protein Antibody
Tuberous sclerosis 2 protein homolog Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of various cell lines, using TSC2 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to TSC2
Application: E, WB, ICC
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: TSC2 (NT) was raised against a 14 amino acid peptide from near the amino terminus of human TSC2.

£301

Description: Rabbit polyclonal antibody to TSC2 (phospho-T1462)
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide corresponding to residues in Human TSC2 around the phosphorylation site of Thr1462.

£175 – £302

Description: Rabbit polyclonal antibody to TSC2
Application: IHC
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide corresponding to residues near the C terminal of human tuberous sclerosis 2

£234

Description: Rabbit polyclonal antibody to TSC2
Application: E, WB
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Raised against a 15 amino acid peptide from near the carboxy terminus of human TSC2.

£301

Please Note: Anti-Tuberin/TSC2 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0491
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe