Specificity
Mouse anti Human Acetylcholine Receptor beta antibody, clone B3 exhibits homogenous, high avidity binding to the beta subunit of nicotinc AChR, an integral membrane and cholinergic receptor, consisting of four further subunits: alpha, delta, gamma (immature muscle) and epsilon (mature muscle). The binding of the neurotransmitter acetylcholine to AChR, results in conformational change affecting all subunits, and initiates the opening of an ion-conducting channel across the plasma membrane of certain neurons, and neuromuscular junctions.Mouse anti Human Acetylcholine Receptor beta antibody, clone B3 has been shown to bind to recombinant AChR beta in Western blotting.
