Anti-alpha 2 Macroglobulin Antibody [M17] (A280996)

Anti-alpha 2 Macroglobulin Antibody [M17]

Mouse monoclonal [M17] antibody to alpha 2 Macroglobulin.

This antibody recognises alpha-2-macroglobulin (A2M), also known as CPAMD5. A2M is a major proteinase inhibitor, with the ability to bind most proteinases and many growth factors, hormones and cytokines in human blood and tissue. A2M is largely produced by the liver under conditions of stress, and is then secreted into the blood and extracellular spaces. It is also produced locally by macrophages, fibroblasts, and epithelial cells. A2M levels dramatically decrease as humans age, a process which has been hypothesized to facilitate tumor development. In naked mole rats, a species with pronounced resistance to cancer, A2M has been shown to inhibit tumor growth regardless of tumor origin. The purified Mouse anti Human A2M antibody, clone M17 (MCA6216GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human A2M antibody, clone M5 (MCA6217B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human A2M (Ser24-Ala1474).

Mouse

Monoclonal

M17

IgG1

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human A2M antibody, clone M17, recognizes alpha-2-macroglobulin (A2M), also known as CPAMD5. A2M is a major proteinase inhibitor, with the ability to bind most proteinases and many growth factors, hormones and cytokines in human blood and tissue (Kurz et al. 2017). A2M is largely produced by the liver under conditions of stress, and is then secreted into the blood and extracellular spaces. It is also produced locally by macrophages, fibroblasts, and epithelial cells (Kim et al. 2017). A2M levels dramatically decrease as humans age, a process which has been hypothesized to facilitate tumor development. In naked mole rats, a species with pronounced resistance to cancer, A2M has been shown to inhibit tumor growth regardless of tumor origin (Kurz et al. 2017).The purified Mouse anti Human A2M antibody, clone M17 (MCA6216GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human A2M antibody, clone M5 (MCA6217B) as the detection antibody.

A2m, A2MG_HUMAN, Alpha 2 M, Alpha 2M, Alpha-2-M, Alpha-2-macroglobulin, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, DKFZp779B086, FWP007, S863 7