Anti-Androgen Receptor Antibody [AR441] (A249053)

Mouse monoclonal [AR441] antibody to Androgen Receptor for Flow Cytometry, IF and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Androgen Receptor Antibody [AR441]
Description
Mouse monoclonal [AR441] antibody to Androgen Receptor.
Specificity
This antibody recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues.
Applications
Flow Cytometry, IF, IHC-P
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Cross Reactivity
This antibody does not cross react with Mouse.
Immunogen
Synthetic peptide corresponding to amino acids 302-318 of human Androgen Receptor.
Sequence
STEDTAEYSPFKGGYTK
Host
Mouse
Clonality
Monoclonal
Clone ID
AR441
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
110 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Androgen Receptor Antibody [AR441] - BSA and Azide free (A252233).
Synonyms
AIS, Androgen nuclear receptor variant 2, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), androgen receptor splice variant 4b, ANDR_HUMAN, AR, AR8, DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor, Dihydrotestosterone receptor (DHTR), HUMARA, HYSP1, KD, Kennedy disease (KD), NR3C4, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), SBMA, SMAX1, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Testicular Feminization (TFM), TFM
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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