Anti-Androgen Receptor Antibody [SPM335] (A249054)

Anti-Androgen Receptor Antibody [SPM335]

Mouse monoclonal [SPM335] antibody to Androgen Receptor.

This antibody recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues.

Flow Cytometry, IF, IHC-P

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

This antibody does not cross react with Mouse.

Synthetic peptide corresponding to amino acids 302-318 of human Androgen Receptor.

STEDTAEYSPFKGGYTK

Mouse

Monoclonal

SPM335

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

110 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Androgen Receptor Antibody [SPM335] - BSA and Azide free (A252234).

AIS, Androgen nuclear receptor variant 2, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), androgen receptor splice variant 4b, ANDR_HUMAN, AR, AR8, DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor, Dihydrotestosterone receptor (DHTR), HUMARA, HYSP1, KD, Kennedy disease (KD), NR3C4, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), SBMA, SMAX1, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Testicular Feminization (TFM), TFM