Anti-BACE2 A/C Antibody (Biotin)
Rabbit polyclonal antibody to BACE2 A/C (Biotin) from FabGennix (BACE2-BIOTIN).
|Name:||Anti-BACE2 A/C Antibody (Biotin)|
|Description:||Rabbit polyclonal antibody to BACE2 A/C (Biotin)|
|Applications:||ELISA, IP, WB|
|Dilutions:||DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500|
|Concentration:||0.72-0.76 µg/µl in antibody stabilization buffer|
|Storage:||-20⁰C for long term storage|
|Function:||Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.|
|Tissue Specificity:||Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.|
|Sequence Similarities:||Belongs to the peptidase A1 family.|
|Post-Translational Modification:||Undergoes autoproteolytic cleavage.|
|Cellular Location:||Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.|
Please Note: Anti-BACE2 A/C Antibody (Biotin) is for research use only. It is not intended for diagnostic of therapeutic use.