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Anti-BAD Antibody

Rabbit polyclonal antibody to BAD from ABclonal (A0741).
Name: Anti-BAD Antibody
Description: Rabbit polyclonal antibody to BAD.
Applications: WB, IHC
Dilutions: WB: 1:100 - 1:200, IHC: 1:50 - 1:100.
Reactivity: Human
Immunogen: A synthetic peptide of human Bad.
Protein Length: 168
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Tissue Specificity: Expressed in a wide variety of tissues.
Sequence Similarities: Belongs to the Bcl-2 family.
Post-Translational Modification: Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.
Cellular Location: Mitochondrion outer membrane. Cytoplasm.

Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm.
UniProt: Q92934
Gene ID: 572
Synonyms: AI325008 Antibody
BAD_HUMAN Antibody
BBC 2 Antibody
BBC2 Antibody
BBC6 Antibody
Bcl 2 Antagonist of Cell Death Antibody
Bcl 2 Binding Component 6 Antibody
BCL X / BCL 2 Binding Protein Antibody
BCL X Binding Protein Antibody
Bcl XL/Bcl 2 Associated Death Promoter Antibody
Bcl-2-binding component 6 Antibody
Bcl-2-like protein 8 Antibody
Bcl-XL/Bcl-2-associated death promoter Antibody
Bcl2 antagonist of cell death Antibody
BCL2 antagonist of cell death protein Antibody
BCL2 associated agonist of cell death Antibody
Bcl2 Associated Death Promoter Antibody
BCL2 binding component 6 Antibody
BCL2 binding protein Antibody
Bcl2 Like 8 Protein Antibody
Bcl2-L-8 Antibody
BCL2L8 Antibody
Proapoptotic BH3 Only Protein Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of various cells, using BAD antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Total Citations (4)
Description: Rabbit polyclonal antibody to Bad (F130)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Bad.

£165 – £283

Total Citations (3)
Description: Rabbit polyclonal antibody to Bad (P130)
Application: WB, IHC, IF
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 100-145 of Human Bad.

£165 – £283

Total Citations (3)
Description: Rabbit polyclonal antibody to Bad (R149)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 112-163 of Human Bad.

£165 – £283

Description: Rabbit monoclonal antibody to Bad
Application: WB, ICC/IF, IHC, FC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant antibody.

£269 – £400

Please Note: Anti-BAD Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0741
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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  • £35 to Europe