Recombinant Anti-Bcl-6 Antibody [rBCL6/1475] - BSA and Azide free (A253082)

Recombinant mouse monoclonal [rBCL6/1475] antibody to Bcl-6 for WB.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Bcl-6 Antibody [rBCL6/1475] - BSA and Azide free
Description
Recombinant mouse monoclonal [rBCL6/1475] antibody to Bcl-6.
Specificity
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000 full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Applications
WB
Dilutions
WB: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 256-389, of human Bcl-6 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
rBCL6/1475
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
95 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Bcl-6 Antibody [rBCL6/1475] (A249902).
Synonyms
B Cell Lymphoma 6 Protein, B-cell CLL/lymphoma 6, B-cell lymphoma 5 protein, B-cell lymphoma 6 protein transcript, BCL5, BCL6A, cys-his2 zinc finger transcription factor, LAZ3, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, ZBTB27, Zinc finger and BTB domain-containing protein 27, Zinc Finger Protein 51, zinc finger transcription factor BCL6S, ZNF51
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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