This antibody recognises human Bcl-2 interacting mediator of cell death (Bim), also known as Bod.Bim is a pro-apoptotic protein within the Bcl-2 family, which functions within the intrinsic apotosis pathway. Bim is known to interact with pro-survival proteins including Bcl-2, Bcl-XL and Bcl-w.Bim is expressed in a variety of cell types, where it is maintained in an inactive conformation by phosphorylation or through binding to the microtubule-associated dynein motor complex. Upon certain apoptotic stimuli, Bim is released from microtubules and mediates caspase-dependent apoptosis.

Applications

WB, IHC-P

Dilutions

WB: 1:1,000

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acids 22-40 of human Bim.

Sequence

AERPPQLRPGAPTSLQTEP

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugate

Unconjugated

Concentration

1 mg/ml

Molecular Weight

Approximately 22 kDa in K562 and A549 whole cell lysates.

Product Form

Liquid

Formulation

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

General Notes

Rabbit anti Human Bim antibody recognizes human Bcl-2 interacting mediator of cell death (Bim), also known as Bod.Bim is a pro-apoptotic protein within the Bcl-2 family, which functions within the intrinsic apotosis pathway. Bim is known to interact with pro-survival proteins including Bcl-2, Bcl-XL and Bcl-w.Bim is expressed in a variety of cell types, where it is maintained in an inactive conformation by phosphorylation or through binding to the microtubule-associated dynein motor complex. Upon certain apoptotic stimuli, Bim is released from microtubules and mediates caspase-dependent apoptosis.

Synonyms

B2L11_HUMAN, BAM, Bcl 2 interacting protein Bim, Bcl 2 related ovarian death agonist, Bcl-2-like protein 11, BCL2 interacting mediator of cell death, BCL2 like 11, BCL2 like 11 (apoptosis facilitator), BCL2 like protein 11, Bcl2-interacting mediator of cell death, Bcl2-L-11, Bcl2l11, BIM alpha6, BIM beta6, BIM beta7, BimEL, BimL, BOD

Isotype Controls

Suitable Secondaries

See all Anti-Rabbit IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

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