Anti-Blood Group Antigen Lewis B Antibody [2-25LE] (A248661)

Anti-Blood Group Antigen Lewis B Antibody [2-25LE]

Mouse monoclonal [2-25LE] antibody to Blood Group Antigen Lewis B.

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.

IF, IHC-P

IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Guinea Pig

Mucin isolated from human ovarian cyst fluid.

Mouse

Monoclonal

2-25LE

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

45 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.