Rabbit anti Human BRCC36 antibody recognizes human BRCA1/BRCA2 complex subunit 36 (BRCC36), a 36.7 kDa nuclear protein.BRCC36, together with BRCA1, BRCA2, Rad51 and BRCC45, forms a holoenzyme complex that possesses an ubiquitin E3 ligase activity. BRCC36 functions in enhancing cellular survival following DNA damage and that it is essential for ionizing radiation induced BRCA1 phosphorylation and nuclear foci formation and BRCC36 is aberrantly expressed in the majority of breast tumors indicating a potential role in the pathogenesis of the disease. BRCC36 could be a potentially important target in the treatment of radiation-resistant breast tumors (Chen et al. 2004).
Applications
WB, IHC-P
Reactivity
Human, Mouse, Rat
Immunogen
An 18 amino acid peptide from near the amino terminus of human BRCC36.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Purification
Affinity chromatography.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
