Rabbit anti C-ABL antibody recognizes tyrosine-protein kinase, also known as ABL1 and JTK7. It was first identified as an oncogene associated with chromosome translocations in human leukemias (Greuber at al. 2013). It regulates cell growth and survival, oxidative stress, DNA-damage responses and cell migration (Hantschel and Superti-Furga 2004). C-ABL plays role in the cellular response to growth factors (Plattner et al. 1999). It phosphorylates EGF R and regulates receptor endocytosis (Tanos and Pendergast 2006). Enhanced C-ABL expression and activation has been detected in solid tumors (Greuber et al. 2013).
Applications
WB, IHC-P
Reactivity
Human
Immunogen
A synthetic peptide corresponding to amino acids 533-545 of human C-ABL.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Purification
Affinity chromatography.
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
